Protein Info for PGA1_c07580 in Phaeobacter inhibens DSM 17395

Annotation: glutathione-regulated potassium-efflux system protein KefC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 630 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 30 to 48 (19 residues), see Phobius details amino acids 54 to 73 (20 residues), see Phobius details amino acids 85 to 107 (23 residues), see Phobius details amino acids 113 to 133 (21 residues), see Phobius details amino acids 146 to 169 (24 residues), see Phobius details amino acids 206 to 228 (23 residues), see Phobius details amino acids 243 to 261 (19 residues), see Phobius details amino acids 264 to 283 (20 residues), see Phobius details amino acids 295 to 315 (21 residues), see Phobius details amino acids 321 to 339 (19 residues), see Phobius details amino acids 351 to 371 (21 residues), see Phobius details amino acids 385 to 406 (22 residues), see Phobius details TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 12 to 310 (299 residues), 247.4 bits, see alignment E=1e-77 PF00999: Na_H_Exchanger" amino acids 15 to 400 (386 residues), 185.4 bits, see alignment E=1.5e-58 PF02254: TrkA_N" amino acids 428 to 542 (115 residues), 85.5 bits, see alignment E=3.4e-28

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 84% identity to sit:TM1040_0579)

Predicted SEED Role

"putative Glutathione-regulated potassium-efflux system protein KefB" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EUT8 at UniProt or InterPro

Protein Sequence (630 amino acids)

>PGA1_c07580 glutathione-regulated potassium-efflux system protein KefC (Phaeobacter inhibens DSM 17395)
MDAFLYQATIYLAAAVIAVPIAARLGLGSVLGYLAAGIIIGPVFGFVGSEAEDLRHFAEF
GVVMMLFLIGLELEPRALWAMRHKLLGLGGLQILVSTMALMGAAMLAGETWQVGLAIGLA
LSLSSTAIVLQTLSEKGLMRTGGGRATFSVLLTQDIAVIPILALLPLLAAQHGAQITGNG
SIARSADDAHAASSHATLSLVEGLPGWAVTLVTLAAIGSIVLAGVYLARPVFRFIHASNL
REMYTALALMIVVGISFLMTLVGLSPALGAFLAGVVLANSEFRHELESDLNPFKGLLLGL
FFITVGAGINYRLFLAEPGDLIGLALLVIIAKGTVLYFVGKAFGLKKRDHWLFTLGLAQA
GEFGFVLLAFSRQLNVVPPELSEKLLLVIALSMLITPLLFILYDLLSKYSKDSPKEQTPD
EIDEEGPVIIAGIGRFGQIVNRLVRASGFNTVVLDSNMASVQLMRRFGVKSFLGDPTRPE
LLKAAGIAKAKVLVVALDDREAALRLVAHARRGYPDLHIIARAFDRNHVFELYKAGANDI
VREMFDSSLRAGRYVLEQIGLSEYEAAQAEQTFYAHDRQTVRELAGLWIPGTPASENPAY
IARARELEKDLETALLELAEAKKSSDQKSA