Protein Info for PGA1_c06310 in Phaeobacter inhibens DSM 17395

Annotation: threonine synthase ThrC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF14821: Thr_synth_N
  • amino acids 2 to 80 (79 residues), 105.2 bits, E=1.6e-34
• TIGR00260: threonine synthase
  • amino acids 94 to 424 (331 residues), 265.5 bits, E=3.4e-83
• PF00291: PALP
  • amino acids 99 to 331 (233 residues), 49.4 bits, E=4.2e-17

Best Hits

KEGG orthology group: K01733, threonine synthase [EC: 4.2.3.1] (inferred from 87% identity to sit:TM1040_2330)

Predicted SEED Role

"Threonine synthase (EC 4.2.3.1)" in subsystem Threonine and Homoserine Biosynthesis (EC 4.2.3.1)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• superpathway of L-isoleucine biosynthesis I (12/13 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (12/15 steps found)
• superpathway of L-threonine biosynthesis (5/6 steps found)
• L-threonine biosynthesis (1/2 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Vitamin B6 metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.1

Sequence Analysis Tools

See I7DMN1 at UniProt or InterPro

Protein Sequence (462 amino acids)

>PGA1_c06310 threonine synthase ThrC (Phaeobacter inhibens DSM 17395)
MKYISTRGQAPELTFEDAMLTGLARDGGLYVPAEIPTMSKDEIAALAGLSYEEVAFRVMR
PFLGDCFTDEEFRGIIARAYDGFGHAARAPLVQLAPNHFLLELFHGPTLAFKDFAMQLIG
QLFETALKRRGESVTIVGATSGDTGSAAIQAFGGLDAVNVFILYPHGRVSEVQRRQMTTP
TDANVHALAVDGDFDDCQAALKDMFNDFDFRDEVRLAGVNSINFARVLAQVVYYFTSAVS
LGAPERKVSFTVPTGNFGDIFAGFIAKQMGLPIDQLVVATNQNDILHRCLSGQGYHKGET
IPSISPSMDIQVSSNFERALFYACGQDGAAVAQLMDELKSGGFEVSQGAMQALQEHYVSG
RCSEEETSATIKSERAASGELLCPHSAIGVKVANEQRDAAVPMVTLATAHPAKFPAAVEE
ASGIHPPLPPRMADLYDRSERVTRIANDLTTLETHIRKHIAH