Protein Info for PGA1_c06240 in Phaeobacter inhibens DSM 17395

Annotation: protein TldD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 473 PF01523: PmbA_TldD_1st" amino acids 33 to 93 (61 residues), 47.1 bits, see alignment E=3.2e-16 PF19290: PmbA_TldD_2nd" amino acids 120 to 229 (110 residues), 69.9 bits, see alignment E=4e-23 PF19289: PmbA_TldD_3rd" amino acids 237 to 470 (234 residues), 213.9 bits, see alignment E=2.5e-67

Best Hits

Swiss-Prot: 45% identical to TLDD_BUCAI: Metalloprotease TldD homolog (tldD) from Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)

KEGG orthology group: K03568, TldD protein (inferred from 87% identity to sit:TM1040_2337)

Predicted SEED Role

"TldD protein, part of TldE/TldD proteolytic complex"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DY41 at UniProt or InterPro

Protein Sequence (473 amino acids)

>PGA1_c06240 protein TldD (Phaeobacter inhibens DSM 17395)
MDTAAFRPFETTLPEDEALGVLRSALAGADDGEIFVERRKSEALVFDDGRLRNASYDAAE
GFGLRAVNGEVAGYAHSTDVSIAGLKRAAETARLAVGDGGGTMAPPPPRTNTRLYTDDDP
IGAMPFAVKVETLREIDAFARAQDPRVVQVSAMLAASLQEVEILRADGTRVRDVRPMTRL
NVSVIVEQDGRRESGSAGGGGRVGLDGLVDPADWQNKVREALRIACVNLEAVPAPAGEMD
VVLGPGWPGILLHEAIGHGLEGDFNRKGSSAFAGLMGQQIAAKGVTVLDDGTLADRRGSI
TVDDEGTPSQKTTLIEDGKLVGFMQDRQNARLMGVESTGNGRRQSYAHAPMPRMTNTYML
GGDANPDDLVASIKDGIWAVGFGGGQVDITNGKFVFSCTEAYRVKDGKVGAPVKGATLIG
DGATALNKIRALGNDMALDPGMGNCGKQGQWVPVGVGQPTVLMGGLTVGGSAT