Protein Info for Psest_0616 in Pseudomonas stutzeri RCH2

Annotation: heavy metal efflux pump (cobalt-zinc-cadmium)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1056 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 347 to 364 (18 residues), see Phobius details amino acids 368 to 388 (21 residues), see Phobius details amino acids 395 to 414 (20 residues), see Phobius details amino acids 452 to 471 (20 residues), see Phobius details amino acids 482 to 507 (26 residues), see Phobius details amino acids 532 to 555 (24 residues), see Phobius details amino acids 881 to 900 (20 residues), see Phobius details amino acids 907 to 926 (20 residues), see Phobius details amino acids 933 to 957 (25 residues), see Phobius details amino acids 980 to 998 (19 residues), see Phobius details amino acids 1010 to 1033 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1047 (1047 residues), 1729.6 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1036 (1032 residues), 1145.3 bits, see alignment E=0

Best Hits

Swiss-Prot: 74% identical to CZCA_ALCSC: Cation efflux system protein CzcA (czcA) from Alcaligenes sp. (strain CT14)

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 77% identity to ajs:Ajs_1849)

MetaCyc: 71% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0GHH0 at UniProt or InterPro

Protein Sequence (1056 amino acids)

>Psest_0616 heavy metal efflux pump (cobalt-zinc-cadmium) (Pseudomonas stutzeri RCH2)
MFERIIRFSIEHRWLVMLAVLGMAALGAYSYQKLPIDAVPDITNVQVQINTAAPGYSPLE
VEQRITYPLETVMAGLPKLEQTRSLSRYGLSQITVIFEEGTDIYFARQLVNERLGGAKDQ
LPDGVTPTLGPISTGLGEIYFWTVEAEEGATKSDGTPYTPADLREIQDWIIKPQVRNVPG
VTEINTIGGYAKEYQIAPNPDTLRSFGLTLQDLIEAVEQNNNNLGAGYIEKRGEQYLVRA
PGQMQSVEDIRDTLISNVDGTPVRIRDVATVEVGKELRTGAATENGREVVLGTAFMLIGE
NSRVVSRAVDDKMKEINLSLPEGVKAITVYDRTVLVDKAISTVKKNLTEGAILVVVILFL
FLGNIRAAILTALVIPLSMLFTFTGMVANQVSANLMSLGALDFGIIIDGAVVIVENCVRR
LAHAQSHHGRALTLSERLHEVFAAAKEVRRPLLYGQLIIMIVYLPIFALTGVEGKMFTPM
AFTVVTALFGAIILSVTFVPAAVALFIGKRVTEKENFLIRNAKRAYAPALDAVMANKPAV
LTFAVVVVILSGLVGSRMGSEFVPSLNEGDFAIQALRVPATSLSQSVEMQQQLERKLMDE
FPEIERIFARTGTAEVASDAMPPNISDGYVMLKPQEQWPDPGKSRNQLLSEVQASAAELP
GNNYEFSQPIQLRFNELISGVRAAVAVKIYGDDMDVLNSTAAEVSEVLGQVPGASEVTVE
QTTGLPMLTIDIDRDQIARYGLSLDTVQQAVAVAIGGREAGTLFQGDRRFDIVVRLPDEI
RSDLAAIERLPIALPRELNSTISYIPLGEVATLDLAPGPNQISREEGKRRIVVSANVRGR
DIGSFVSEAEQKIQAQVDIPAGYWIDWGGTFEQLESATKRLQIVVPVALLLVFILLFMMF
NNVKDGLLVFTGIPFALTGGIVALWLRDIPLSISAGVGFIALSGVAVLNGLVMISFIRSL
REQGLPLDTAIREGALTRLRPVLMTALVASLGFVPMALNVGTGAEVQRPLATVVIGGILS
STVLTLLVLPLLYQMAHRREDELEEQEIALAADRTS