Protein Info for Psest_0551 in Pseudomonas stutzeri RCH2

Annotation: PEP phosphonomutase and related enzymes

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13714: PEP_mutase
  • amino acids 13 to 249 (237 residues), 141.4 bits, E=1.9e-45

Best Hits

Swiss-Prot: 100% identical to OADC_PSEU5: Oxaloacetate decarboxylase (PST_3733) from Pseudomonas stutzeri (strain A1501)

KEGG orthology group: K01003, carboxyvinyl-carboxyphosphonate phosphorylmutase [EC: 2.7.8.23] (inferred from 100% identity to psa:PST_3733)

MetaCyc: 76% identical to oxaloacetate decarboxylase monomer (Pseudomonas aeruginosa)
Malate dehydrogenase (oxaloacetate-decarboxylating). [EC: 1.1.1.38, 1.1.1.40, 1.1.1.83, 4.1.1.112]

Predicted SEED Role

"Carboxyphosphonoenolpyruvate phosphonomutase (EC 2.7.8.23)" (EC 2.7.8.23)

MetaCyc Pathways

• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (23/26 steps found)
• superpathway of glyoxylate bypass and TCA (11/12 steps found)
• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (18/22 steps found)
• TCA cycle I (prokaryotic) (9/10 steps found)
• gluconeogenesis I (11/13 steps found)
• superpathway of glyoxylate cycle and fatty acid degradation (11/14 steps found)
• TCA cycle VIII (Chlamydia) (5/6 steps found)
• glyoxylate cycle (5/6 steps found)
• TCA cycle II (plants and fungi) (7/9 steps found)
• TCA cycle V (2-oxoglutarate synthase) (7/9 steps found)
• mixed acid fermentation (12/16 steps found)
• TCA cycle III (animals) (7/10 steps found)
• malate/L-aspartate shuttle pathway (1/2 steps found)
• TCA cycle IV (2-oxoglutarate decarboxylase) (6/9 steps found)
• gluconeogenesis III (8/12 steps found)
• chitin deacetylation (2/4 steps found)
• C4 photosynthetic carbon assimilation cycle, NADP-ME type (4/7 steps found)
• anaerobic energy metabolism (invertebrates, cytosol) (4/7 steps found)
• C4 photosynthetic carbon assimilation cycle, PEPCK type (9/14 steps found)
• gentisate degradation II (1/4 steps found)
• C4 photosynthetic carbon assimilation cycle, NAD-ME type (6/11 steps found)
• reductive TCA cycle I (6/11 steps found)
• incomplete reductive TCA cycle (3/7 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (5/10 steps found)
• methylgallate degradation (2/6 steps found)
• protocatechuate degradation I (meta-cleavage pathway) (3/8 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (9/17 steps found)
• reductive TCA cycle II (5/12 steps found)
• pyruvate fermentation to propanoate I (1/7 steps found)
• superpathway of vanillin and vanillate degradation (3/10 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (5/13 steps found)
• formaldehyde assimilation I (serine pathway) (5/13 steps found)
• methylaspartate cycle (9/19 steps found)
• syringate degradation (3/12 steps found)
• L-glutamate degradation VIII (to propanoate) (1/11 steps found)
• phosalacine biosynthesis (4/25 steps found)
• phosphinothricin tripeptide biosynthesis (4/25 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (21/56 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of terpenoids and steroids
• Butanoate metabolism
• Carbon fixation in photosynthetic organisms
• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.40

Use Curated BLAST to search for 1.1.1.38 or 1.1.1.40 or 1.1.1.83 or 2.7.8.23 or 4.1.1.112

Sequence Analysis Tools

See L0GEK0 at UniProt or InterPro

Protein Sequence (287 amino acids)

>Psest_0551 PEP phosphonomutase and related enzymes (Pseudomonas stutzeri RCH2)
MPRLSHHDLRRNFRELLNADRCFHTASVFDPMSARIAADLGFEVGILGGSVASLQVLAAP
DFNLITLSEFVEQATRICRVAQLPVLADADHGYGNALNVMRTVSELERAGISALTIEDTL
LPPKFGRRSTDLIGMFEAVGKIRAALEARVDPEMAIIGRTNAGVIGFEEVIARAQAYEKA
GADAICLVGIEDFDHLESIASQLSKPLMLVTYGNPNLRDNARLASLGVRIVVNGHAAYFA
AIKATYDCLREQRQVDALDLNASQLSVKYSTADEYVVWAEEYMQVKE