Protein Info for Psest_0535 in Pseudomonas stutzeri RCH2

Annotation: glutamate-1-semialdehyde-2,1-aminomutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 427 TIGR00713: glutamate-1-semialdehyde-2,1-aminomutase" amino acids 4 to 425 (422 residues), 622.8 bits, see alignment E=1.3e-191 PF00202: Aminotran_3" amino acids 32 to 394 (363 residues), 253.2 bits, see alignment E=3.7e-79 PF00155: Aminotran_1_2" amino acids 182 to 395 (214 residues), 20.8 bits, see alignment E=2e-08

Best Hits

Swiss-Prot: 98% identical to GSA_PSEU5: Glutamate-1-semialdehyde 2,1-aminomutase (hemL) from Pseudomonas stutzeri (strain A1501)

KEGG orthology group: K01845, glutamate-1-semialdehyde 2,1-aminomutase [EC: 5.4.3.8] (inferred from 98% identity to psa:PST_3758)

MetaCyc: 66% identical to glutamate-1-semialdehyde 2,1-aminomutase (Escherichia coli K-12 substr. MG1655)
Glutamate-1-semialdehyde 2,1-aminomutase. [EC: 5.4.3.8]

Predicted SEED Role

"Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 5.4.3.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.3.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0GHA0 at UniProt or InterPro

Protein Sequence (427 amino acids)

>Psest_0535 glutamate-1-semialdehyde-2,1-aminomutase (Pseudomonas stutzeri RCH2)
MSRSETLFASAQTHIPGGVNSPVRAFRSVGGTPLFLKHAAGAYVIDEDDKRYVDYVGSWG
PMILGHSHPEVLDAVRRQLEHGLSYGAPTAMETEMAELVCRLVPSMEMVRMVSSGTEATM
SAIRLARGYTGRDAIIKFEGCYHGHSDSLLVKAGSGTLTLGVPSSAGVPADFAKHTLTLA
YNDLAEVEATLKEKGEQVACIIVEPVAGNMNCVPPAPGFLEGLRSLCDAHGVVLIFDEVM
TGFRVALGGAQAYYGVTPDLSTFGKIIGGGMPVGCFGGKRAIMERIAPLGPVYQAGTLSG
NPLAMAAGLTTLGLISRPGFHDELSAYTSRMLQGLQDRADAAGIPFVTTQVGGMFGLYFS
GADDIVTFADVMASDADRFKRFFHLMLEGGVYLAPSAFEAGFTSIAHGDTELAITLEAAE
RAFAKLK