Protein Info for HP15_458 in Marinobacter adhaerens HP15

Annotation: transcriptional regulator, LysR family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 296 PF00126: HTH_1" amino acids 6 to 63 (58 residues), 67.5 bits, see alignment E=8.1e-23 PF03466: LysR_substrate" amino acids 88 to 293 (206 residues), 117.2 bits, see alignment E=6.7e-38

Best Hits

KEGG orthology group: K03576, LysR family transcriptional regulator, regulator for metE and metH (inferred from 78% identity to maq:Maqu_0810)

Predicted SEED Role

"Transcriptional activator MetR" in subsystem Methionine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PMU4 at UniProt or InterPro

Protein Sequence (296 amino acids)

>HP15_458 transcriptional regulator, LysR family protein (Marinobacter adhaerens HP15)
MIERSHLEILRAVNQQGSLTAAAECLHLTQSALSHSIRKLEHQFGTDIWVREGRQLRLTQ
SGEYLLSLANRLLPQMEHAEMLIGQFARGQRGTLRIGMECHPCYQWLLKVVGPYLEGWPG
VDVDVKQKFQFGGIGALFGHDIDMLVTPDPLQRPGLVFEPVFDYEQVLVVAADHALADKA
WAEPGDLEKETLITYPVEIERLDIYTRFLLPAHASPARHKTIETTDIMLQMVAAGRGVAA
LPRWLVEDYGARIPVRPVQLGETGIPKQIFLGLRERDREVDYLNSFMKLAREVRWN