Protein Info for HP15_47 in Marinobacter adhaerens HP15

Annotation: fumarylacetoacetate (FAA) hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 288 PF10370: Rv2993c-like_N" amino acids 1 to 65 (65 residues), 22.1 bits, see alignment E=2.4e-08 PF01557: FAA_hydrolase" amino acids 72 to 278 (207 residues), 201.6 bits, see alignment E=1.3e-63

Best Hits

KEGG orthology group: None (inferred from 68% identity to bxe:Bxe_C0595)

Predicted SEED Role

"Fumarylacetoacetate hydrolase family protein" in subsystem Gentisare degradation or Salicylate and gentisate catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PIA6 at UniProt or InterPro

Protein Sequence (288 amino acids)

>HP15_47 fumarylacetoacetate (FAA) hydrolase (Marinobacter adhaerens HP15)
MKLARFSYKGSVPAWGVVDLEHQEINPIKERFEDWAPLVTAGAGISAVSFSSGPLAIKEV
TLLPPIEPVNRVVVAGANYLKHLKDDFSLEPPKQPIAFLKAYGALIGADDPIRFPPLTEE
LDYEVELVVVIGSKEVDTTKPYDSVLGYTVGNDVSARDLQRSGPKGIGMDLFAAKSQDKT
TGLGPWIVTRDEFPEGMPALRLTLSVNGEVRQDGNTSEMTWTVAELITFVHERSSFACGD
VLFTGSPAGVGMATGRFLNPGDVVEASVEGVGTLRNVVGERSNKRLGK