Protein Info for PGA1_c00460 in Phaeobacter inhibens DSM 17395

Annotation: adenylate cyclase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00211: Guanylate_cyc
  • amino acids 223 to 395 (173 residues), 64.2 bits, E=6.3e-22

Best Hits

KEGG orthology group: K01768, adenylate cyclase [EC: 4.6.1.1] (inferred from 58% identity to sit:TM1040_2619)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1) / Guanylate cyclase (EC 4.6.1.2)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1, EC 4.6.1.2)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1, 4.6.1.2

Use Curated BLAST to search for 4.6.1.1 or 4.6.1.2

Sequence Analysis Tools

See I7DWI6 at UniProt or InterPro

Protein Sequence (404 amino acids)

>PGA1_c00460 adenylate cyclase domain-containing protein (Phaeobacter inhibens DSM 17395)
MTDAASRATPIIDWLTAEGLRGASRQEMLQGFCQRLADIGVPLLRFHLAQRAYHPKYGGI
GFSWTRSDGLSHEFYEHSDTPRDEWLYSTFYYMLERDVPEFRSKLTGHVLERFPALAQFK
QRGATDYFALAKRFGDFADAPFDPRRPGEGILSSWSTDHPEGFTDADLALIRQIYSHLAL
ALRAASAQQMAKDLLQVYLGRDAGQRVLSGEIQRGSSRQIDAVICYFDLKGFTQLAEQIP
GAELIDMLNDYFGLAVETIQSHGGNILKFMGDGILSMFDLGSIGEDATAALAAASALQGK
IRNRNTQRSAQGVPTADFTLALHAGEILYGNIGSENRLDFTVIGPTVNLTARISGMHTSV
GRSIIVSEQVQKAAQPTSHDLVSLGRYMLRGVAEPVELFTIYEG