Protein Info for HP15_p42g49 in Marinobacter adhaerens HP15

Annotation: type IV secretion/conjugal transfer ATPase, VirB4 family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 846 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details TIGR00929: type IV secretion/conjugal transfer ATPase, VirB4 family" amino acids 37 to 835 (799 residues), 768 bits, see alignment E=5.8e-235 PF03135: CagE_TrbE_VirB" amino acids 224 to 426 (203 residues), 105.4 bits, see alignment E=4.1e-34 PF19044: P-loop_TraG" amino acids 619 to 748 (130 residues), 32.9 bits, see alignment E=2.9e-12

Best Hits

KEGG orthology group: K03199, type IV secretion system protein VirB4 (inferred from 85% identity to bam:Bamb_6632)

Predicted SEED Role

"Conjugative transfer protein TrbE" in subsystem Type 4 secretion and conjugative transfer

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PRV9 at UniProt or InterPro

Protein Sequence (846 amino acids)

>HP15_p42g49 type IV secretion/conjugal transfer ATPase, VirB4 family (Marinobacter adhaerens HP15)
MMIQAISFAIAVCGAALLLILFARIRAVDAELKLKKHRSKDAGLADLLNYAAVVDDGVIV
CKNGAFMASWLYKGDDNASSTDEQREMVSFRINQALAGLGNGWMVHVDAVRRPAPNYSER
NTSAFPDPVSAAIDEERRQLFEGLGAMYEGYFVLTLTWFPPLLAQRKFVELMFDDDAEVV
GKKARTKGLINQFKREISGIENRLTTAVKLTRLRGQKIVNEDGSKVTHDDFLSWLQFCVT
GVSHPVQLPNNPMYMDAYIGGQEMWGGVVPKVGRKFIQVVSIEGFPLESHPGILSALAEL
PVEYRWSSRFIFMDQHESIKHLDKFRKKWKQKVRGFFDQVFNTNSGNVDQDALTMVQDAE
SAIAEVNSGLVAVGYYTSVVVLMDESRDRLEQSARQVEKSINRLGFAARTETINTLDAYL
GSLPGHGVENVRRPLINTMNLADLLPTSTIWTGNADAPCPMYPPLSPALMHCVTSGSTPF
RLNLHVRDLGHTFMFGPTGAGKSTHLALIAAQLRRYAGMSIFAFDKGMSMYPLTKAVGGL
HFSVGADDDHLSFCPLQYLETKSDRAWAMEWIDTILALNGVQSTPAQRNEIAHAIVSMHE
SGARTLSEFSLTIQDESIREAIRQYTVDGSMGHLLDADEDGLSLTDFTTFEIEELMNLGE
KFALPVLLYLFRRIERSLKGQPAVIILDEAWLMLGHPAFREKIREWLKVLRKANCLVLMA
TQSLSDAANSGILDVIVESTATKIFLPNVYARDEDTSALYRRMGLNARQIDILATAVPKR
QYYYVSENGRRLYDLALGPLALSFVGASDKESVAAIKQLEAKYGEQWVHEWLAGRGLKLD
NYLEAA