Protein Info for HP15_4175 in Marinobacter adhaerens HP15

Annotation: formate dehydrogenase, subunit FdhD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00129: formate dehydrogenase family accessory protein FdhD
  • amino acids 43 to 282 (240 residues), 218.2 bits, E=5.6e-69
• PF02634: FdhD-NarQ
  • amino acids 47 to 283 (237 residues), 235.3 bits, E=4.3e-74

Best Hits

Swiss-Prot: 54% identical to FDHD_CUPNH: Sulfur carrier protein FdhD (fdhD) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: K02379, FdhD protein (inferred from 57% identity to hse:Hsero_1478)

Predicted SEED Role

"Formate dehydrogenase chain D (EC 1.2.1.2)" in subsystem Formate hydrogenase (EC 1.2.1.2)

MetaCyc Pathways

• formate oxidation to CO₂ (1/1 steps found)
• oxalate degradation VI (1/4 steps found)
• oxalate degradation III (1/5 steps found)
• superpathway of C1 compounds oxidation to CO₂ (4/12 steps found)
• purine nucleobases degradation I (anaerobic) (5/15 steps found)
• purine nucleobases degradation II (anaerobic) (11/24 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Methane metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Sequence Analysis Tools

See E4PMN1 at UniProt or InterPro

Protein Sequence (284 amino acids)

>HP15_4175 formate dehydrogenase, subunit FdhD (Marinobacter adhaerens HP15)
MSLPLSKVEDAVMAPGTQEQALPSTVFETTVDVCGGIEGTPNSDQVAEEVPVAMVYNGIS
HAVMMASPSDLEDFGLGFSLSEGIIDCPEQLFQLDVGVGKQGITLEMHVAGECFARLKEQ
RRNMAGRTGCGLCGTESLSQAVRPIQEVPNHTSPHNRSVQVALHGLRQHQPLQSETGATH
GAAWCDSEGMIQTIREDIGRHNALDKLIGARIARYGPNAFNDGFALISSRASFEMVQKSA
GVGIRCLVAVSAATALAIRRAEEAGMTLIGFARPGRHVIYTRKH