Protein Info for HP15_4131 in Marinobacter adhaerens HP15

Annotation: formate dehydrogenase family accessory protein FdhD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00129: formate dehydrogenase family accessory protein FdhD
  • amino acids 32 to 265 (234 residues), 142.3 bits, E=8.1e-46
• PF02634: FdhD-NarQ
  • amino acids 34 to 265 (232 residues), 248.4 bits, E=4.2e-78

Best Hits

KEGG orthology group: K02379, FdhD protein (inferred from 70% identity to dsh:Dshi_3282)

Predicted SEED Role

"Formate dehydrogenase chain D (EC 1.2.1.2)" in subsystem Formate hydrogenase (EC 1.2.1.2)

MetaCyc Pathways

• formate oxidation to CO₂ (1/1 steps found)
• oxalate degradation VI (1/4 steps found)
• oxalate degradation III (1/5 steps found)
• superpathway of C1 compounds oxidation to CO₂ (4/12 steps found)
• purine nucleobases degradation I (anaerobic) (5/15 steps found)
• purine nucleobases degradation II (anaerobic) (11/24 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Methane metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Sequence Analysis Tools

See E4PMI7 at UniProt or InterPro

Protein Sequence (289 amino acids)

>HP15_4131 formate dehydrogenase family accessory protein FdhD (Marinobacter adhaerens HP15)
MTIDPILPDPTDPRLSRPVEGVDENGEAKSISVIEERPLTIYLNSQEIVTAMTIGDHPEY
LALGFLLNQGMLKETDEVTGIDFDEELEVAVVRTSSVTDVEDKLEKKTRTSGCAVGTVFG
DMMAGLEGLSLPDTPVHTSTFYDLSYQINHTPSLYMETGAIHGTALCQGQKILAYMEDVG
RHNAVDKIAGWMHLNNISAADKVLYTTGRLTSEMVIKTSLMGIPTLISRSGFTAWGVDIA
RQVGLTLIGRMRGKKFTCLSGQHRLVFDQDLSQVPDEDKKLRRKGAQHD