Protein Info for HP15_406 in Marinobacter adhaerens HP15

Annotation: excinuclease ABC, ATPase subunit (A)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 946 TIGR00630: excinuclease ABC subunit A" amino acids 4 to 923 (920 residues), 1497.9 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 130 to 235 (106 residues), 133.2 bits, see alignment E=1.4e-42 PF17755: UvrA_DNA-bind" amino acids 289 to 397 (109 residues), 129.3 bits, see alignment E=3e-41

Best Hits

Swiss-Prot: 72% identical to UVRA_HAEIN: UvrABC system protein A (uvrA) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 76% identity to abo:ABO_0427)

MetaCyc: 73% identical to UvrABC excision nuclease subunit A (Escherichia coli K-12 substr. MG1655)
3.1.25.-

Predicted SEED Role

"Excinuclease ABC subunit A" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PMP2 at UniProt or InterPro

Protein Sequence (946 amino acids)

>HP15_406 excinuclease ABC, ATPase subunit (A) (Marinobacter adhaerens HP15)
MDHIQIKGARTHNLKNIDLDMPRDKLIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSTY
ARQFLSMMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEIYDYLRLLFARAGEPRC
PDHGQPLEAQTISQMVDQVVAMPADSKLMILAPVIRDRKGEHLQVIETMRSQGFIRVRVD
GTVYDIDDVPALDKKRKHQIDVVVDRFKVKPGLEQRLAESFETALDLADGIALVAPMSGE
GEEQTFSARYACTQCGYALSELEPKLFSFNNPAGACPTCDGLGVKQFFDPEKIVQHPEAT
LASGAIKGWDRRAVYYFQMLGSVADHYGIDLETPWADLPEDFRNVLLFGSGDEDIPFRYV
NSRGHIMEKAHPFEGILPNLERRYRETDSQSMREELARNLSTQPCKECGGSRLRRSARHV
FIEEHNISDVTHLPVGDAHDYFETLALPGRKGEIAEKILKEVRQRLQFLVNVGLEYLTLE
RSADTLSGGEAQRIRLASQIGAGLVGVMYILDEPSIGLHQRDNDRLLATLTHLRDLGNTV
IVVEHDEDAIRAADHVIDIGPGAGVHGGKVIGQGTPQQIIDNPDSLTGQYLNGTREIAIP
KQRNKGSGKTLTLSGATGNNLKDVTLDLPLGIMTCVTGVSGSGKSTLINSTLYPVAAAKL
NKATSLNHAPYQSLKGLDHLDKVIDIDQSPIGRTPRSNPATYTGLFTPIRELFAGTQEAR
SRGYKPGRFSFNVKGGRCEACQGDGVIKVEMHFLPDIYVPCDVCKGKRYNRETLEVRYKG
KNINEVLEMTVEEGREFFDAVPFLARKLQTLMDVGLSYIRLGQSAVTLSGGEAQRVKLAK
ELSKRDTGKTLYILDEPTTGLHFYDIQQLLNVLERLRDHGNTIVVIEHNLDVIKTADWIV
DLGPEGGSGGGQIIAEGTPEEVAENPASHTGRYLKPMLTKSLAGKK