Protein Info for HP15_4115 in Marinobacter adhaerens HP15

Annotation: sensory box/GGDEF/EAL family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 811 PF08447: PAS_3" amino acids 43 to 123 (81 residues), 32.1 bits, see alignment E=3.9e-11 amino acids 162 to 232 (71 residues), 49.1 bits, see alignment E=1.9e-16 amino acids 280 to 352 (73 residues), 28.1 bits, see alignment E=6.9e-10 TIGR00229: PAS domain S-box protein" amino acids 136 to 251 (116 residues), 56.3 bits, see alignment E=3.5e-19 amino acids 262 to 378 (117 residues), 63.9 bits, see alignment E=1.6e-21 PF13426: PAS_9" amino acids 155 to 249 (95 residues), 28.1 bits, see alignment E=7.2e-10 amino acids 269 to 369 (101 residues), 58.3 bits, see alignment E=2.9e-19 PF13188: PAS_8" amino acids 261 to 308 (48 residues), 30.3 bits, see alignment 1e-10 PF00989: PAS" amino acids 262 to 368 (107 residues), 47.5 bits, see alignment E=5.9e-16 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 379 to 541 (163 residues), 156.6 bits, see alignment E=4.7e-50 PF00990: GGDEF" amino acids 382 to 538 (157 residues), 177.2 bits, see alignment E=7.8e-56 PF00563: EAL" amino acids 559 to 793 (235 residues), 255 bits, see alignment E=2.2e-79

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PMH1 at UniProt or InterPro

Protein Sequence (811 amino acids)

>HP15_4115 sensory box/GGDEF/EAL family protein (Marinobacter adhaerens HP15)
MSSDPLFSTPGEENALYLELTDGIPGAIFQYILHPDGTDQLSYISRGCVDLWEIEAAELK
RDPGPLWEMILPEDVEGLARSIRGSAETMTFWRHEWRIKPASGVVKWLSGTGTPKQRENG
DICWNSVIIDVTRERQTQEALDSFFDQRMTMNAMVDFEGKFVRVNGLWETKLGYRRDELE
GEVFIEFVHPEDREKTLSEAGRVIENSEGSSEFENRYRHKDGFYRWLSWSSVTSPEAGLI
YAVAIDVTEARIADDKLRQAATVFQSTVEGVMISDLDNRIIEVNDAFSQITGYTEEEAIG
KTPDLLDSGKHDPSFFNAIWQSVRENGHWRGEIWSRRKDGSVFPELLTISTILNKDEPVG
YVTVFSDISTLKAHQEKLDYLAHHDPLTGLPNRLLFNSRLQQSIRLSERTGRSIAVLFID
IDRFKNINDSMGHPTGDELLKHVAARLREQLRASDTAARLGGDEFVVLLEDIEGAEHAGQ
VADTLMKAFKETFAMDGVEIGVTVSMGISLFPQDSNDAAELLADADAAMYQAKENGRNTY
AFYSSESTARALEYVFFENALRRAVSDNQLFLEYQPQFDLEPGKLTGMEALIRWQHPDKG
LITPDRFIPIAEQNGTIRNIGQWVLQTACHQGKAWLDAGLDIGRISINVAASQFHDENFL
AEVLAIVDESGLPPEHLELELTESSFMHQPERAIPKLHALRERNITIAIDDFGTGFSSLS
YLKRLPIDKLKIDRSFVMDLPDDEEDKAIVRAIIGLGKTLKLKTIAEGVETEAQVAFFKQ
AKCDAQGFYFSRPLGTDAMDAFLRSPQTTTL