Protein Info for HP15_4023 in Marinobacter adhaerens HP15

Annotation: helix-turn-helix, Fis-type

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 568 PF06505: XylR_N" amino acids 16 to 116 (101 residues), 121.7 bits, see alignment E=3.9e-39 PF02830: V4R" amino acids 139 to 189 (51 residues), 41.3 bits, see alignment 4.9e-14 PF14532: Sigma54_activ_2" amino acids 236 to 406 (171 residues), 70.4 bits, see alignment E=7.8e-23 PF00158: Sigma54_activat" amino acids 236 to 401 (166 residues), 230.7 bits, see alignment E=3.3e-72 PF00004: AAA" amino acids 259 to 380 (122 residues), 21.9 bits, see alignment E=8.5e-08 PF07728: AAA_5" amino acids 259 to 378 (120 residues), 31.8 bits, see alignment E=5.5e-11 PF01078: Mg_chelatase" amino acids 314 to 384 (71 residues), 21.3 bits, see alignment E=6.1e-08 PF02954: HTH_8" amino acids 521 to 561 (41 residues), 33.9 bits, see alignment 8.3e-12

Best Hits

Swiss-Prot: 70% identical to XYLR_PSEPU: Transcriptional regulatory protein XylR (xylR) from Pseudomonas putida

KEGG orthology group: None (inferred from 79% identity to pmy:Pmen_3204)

Predicted SEED Role

"Positive regulator of phenol hydroxylase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PKW5 at UniProt or InterPro

Protein Sequence (568 amino acids)

>HP15_4023 helix-turn-helix, Fis-type (Marinobacter adhaerens HP15)
MAISYKPQLQYADFQDLTEQIRFQSTEGKIWFGEQRMLLMQVSAMAAFRREMVNTIGIER
AKGFFLRLGYQSGLRDAELARKLRPHCSELDIFLAGPQLHSLKGMVKVIPIEIDIDQDTG
GFYGELDWFDSFEVEICQTELGQMDEPACWSLLGYACAYTSSFMGRQIIFKEVTCRGCGD
EKCHIVGKPAEEWEDSEEFIKYFKADPMIEELYDLQSQVSSLRSSLENQQGQYYGIGQSA
SYNKVCKMIDKAAMGKVSVLLLGETGVGKEVIARSVHLRSERAEQPFVAVNCAAIPPDLI
EAELFGVEKGAYTGANQSRPGRFERANGGTIFLDEVVELTARAQATLLRVLQEGELERVG
DNRTRSVNVRVIAATNESLAEAVESGKFRADLYYRLNVFPVKIPPLRDRLEDLPLLVEHF
LKKFHSEYNKRTLGLSDKALALCMNYRWPGNIRELENVIERGVILTDNNESISQESLFAV
FPDNHSEKPHEVVDGEGHVVHEGSPGNSGGWADQILGDSISLDEVEETLMRRAMEQANQN
VSGAARILGLTRPALAYRLKKSGILAEN