Protein Info for HP15_4003 in Marinobacter adhaerens HP15

Annotation: transporter, AcrB/AcrD/AcrF family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1033 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 311 to 330 (20 residues), see Phobius details amino acids 336 to 357 (22 residues), see Phobius details amino acids 363 to 383 (21 residues), see Phobius details amino acids 409 to 434 (26 residues), see Phobius details amino acids 440 to 463 (24 residues), see Phobius details amino acids 517 to 539 (23 residues), see Phobius details amino acids 857 to 875 (19 residues), see Phobius details amino acids 882 to 902 (21 residues), see Phobius details amino acids 908 to 932 (25 residues), see Phobius details amino acids 954 to 973 (20 residues), see Phobius details amino acids 985 to 1011 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 2 to 1007 (1006 residues), 561.9 bits, see alignment E=2.6e-172 PF03176: MMPL" amino acids 852 to 1023 (172 residues), 33.6 bits, see alignment E=2.1e-12

Best Hits

KEGG orthology group: None (inferred from 84% identity to maq:Maqu_0308)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PKU5 at UniProt or InterPro

Protein Sequence (1033 amino acids)

>HP15_4003 transporter, AcrB/AcrD/AcrF family protein (Marinobacter adhaerens HP15)
MMLVMLLGGVLALTRMNIQFFPTFALDVVSVRVVWSGASAEDVEQGITNPLEQRLRSVDG
LKKMTSTSAQSVSSITLEFEEGTNPIQALDDVRQQVDEFTNFPAEAEEPQVTRIERYEPV
ARLLVYGDVDRSELRQMAYRFEDELLQRGIDRVSIRGLPEQQISIDVPVERLETLGLSLE
QIAERVAAISRDLPAGMMAQQDATRELRAVEQRRSPQEFENIPVLSGERVQLHLGDVAII
RQEARESQVTLEKDGKPAVELQLQRSENGNSLEAAKVLENWLTDTRPVLPPTVELEVYDE
TWQLLDDRISLLVKNGLGGLVLVICLLYLFLPGRVALWVAVGIPTAFLAAMAVLWLIGGS
INMISLFALIMALGVIVDDAIVVGEDADAHARMGEESIYASEGAAKRMVWPVLASSLTTV
AAFMPLLVVGGVIGNILGDIPLVMICVLVASLLECFIVLPAHLRHAFVPRRKKKSQASEP
KKPGPIERFRQGFEQRFDRFREGRFRRFSRYSLQHRGATVASALALAIVTIGLLAGGRLG
FNFFPTPEPSVFYANASFVAGTDRGTVDDFLTQMQTTLNETEEALGGDFILHAVTTRGAT
QGAEGSSRSGDELGSMMIELVPSDRRSVRNPEFITEWRSRLETPAGLDNLTISERQAGPP
GRDVNVRLTGENAERLKQAADELGQALSTLPGVLDVEDDMPWGREQLIYQVSAYGEALGL
TTSDLGRQLRAAFDGRIAQIYQDGRDEVEVRVQLPQDQRERLSTLSRITIRVPDGRFVPL
TQVMNLDHRQGFQALRHAEGRLAVEVTSGLNTRVSTTDQILTSLEAEALPDIASRYNVRY
SFEGRAADQRETLGDMQTGLVIGLALMYVVLAWVFASWSLPLIVMAIIPFALVGALLGHW
LMGLQLTILSLFGLFGLSGIVVNNAIILVAFYNQQRKKGLDITDALNEAAVQRVRAVMLT
SLTTIGGLLPLLFETSLQAQFLIPMATSIAFGLGLSTLLVLLVVPALLSWLEQFREWRAR
RHGEMAEPIGAPE