Protein Info for HP15_3958 in Marinobacter adhaerens HP15

Annotation: rhodanese domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00581: Rhodanese
  • amino acids 7 to 126 (120 residues), 46.2 bits, E=2.8e-16
  • amino acids 160 to 275 (116 residues), 42.6 bits, E=3.7e-15

Best Hits

KEGG orthology group: K01011, thiosulfate/3-mercaptopyruvate sulfurtransferase [EC: 2.8.1.1 2.8.1.2] (inferred from 52% identity to sfr:Sfri_3019)

Predicted SEED Role

"Thiosulfate sulfurtransferase, rhodanese (EC 2.8.1.1)" (EC 2.8.1.1)

MetaCyc Pathways

• thiosulfate disproportionation IV (rhodanese) (1/1 steps found)
• L-cysteine degradation III (1/2 steps found)
• sulfide oxidation IV (mitochondria) (3/5 steps found)

KEGG Metabolic Maps

• Cysteine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.8.1.1 or 2.8.1.2

Sequence Analysis Tools

See E4PKQ0 at UniProt or InterPro

Protein Sequence (282 amino acids)

>HP15_3958 rhodanese domain protein (Marinobacter adhaerens HP15)
MASPLVTTDWLQENLDNERLVLIDASMATVIGKEPIVYDHPVWIPGSFQIDLEGTLCNTE
SSQLHAFPTEEQFTQEVRRLGITPERLVVLYDNQGIYSAPRAWWILRSMGLEQVFVLDGG
LPQWLAEGRETVSAPINSAASAGNMAGRLDRGRVRDSAFVLQHLDDERVSVIDARSRARF
LAQAPEPRPGVRGGHIPNSLSLPFTEVLDGYRFKPVSELEAKFRHLGTNLQPGDGHQLVF
SCGSGITACIILLAAELAGYDQLSLYDGSWADWGSDDSLPVA