Protein Info for HP15_3951 in Marinobacter adhaerens HP15

Annotation: signal-transduction protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 624 PF00027: cNMP_binding" amino acids 36 to 118 (83 residues), 53.2 bits, see alignment E=4.8e-18 PF00571: CBS" amino acids 155 to 207 (53 residues), 34.9 bits, see alignment 3.3e-12 amino acids 220 to 272 (53 residues), 46.2 bits, see alignment 9.4e-16 PF03445: DUF294" amino acids 300 to 434 (135 residues), 151.9 bits, see alignment E=2.1e-48 PF10335: DUF294_C" amino acids 472 to 616 (145 residues), 154.5 bits, see alignment E=3.5e-49

Best Hits

KEGG orthology group: K07182, CBS domain-containing protein (inferred from 86% identity to maq:Maqu_0267)

Predicted SEED Role

"Predicted signal-transduction protein containing cAMP-binding and CBS domains" in subsystem cAMP signaling in bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PK05 at UniProt or InterPro

Protein Sequence (624 amino acids)

>HP15_3951 signal-transduction protein (Marinobacter adhaerens HP15)
MQAELVDIRNHMAQYPPFDEMAEELLDRVVGDIEIVYFKAGSQILELGDPSSWLYYVRSG
AVEIYRRTGELYNRISEGEVFGQFGLLMNRKVRFPAKALEDVLLYKIPYDTFQYLWENDD
NFADFVEIEDRSRLRSAVSRREKSNQLMTSKVTRLIAREPVSAPHTVRLQEAARIMTENG
VSALLLMDEEGEKPLLKGIITDRDLRTRALSEALASETPISEIMSEDLITIRSNMFIFEA
MLTMLHNNVHHLPVMDRDEVRGVIALSDIVKYESQSSLYLVSNIYHQQDVKGLKKISLDV
RDSFVRMVNEDANSHMIGSAMAGIGRSFTQRLLTLGEEKLGPPPVPYCFMALGSMARDEQ
LVVTDQDNAMILDDSFVPEEHDEYFLALAKFVSDGLAECGYTYCTGDIMATNQKWRQPLR
VWKDYFTDWIDNPKAEALLNSNIFFDLDGIYGETDFAEQLKTLVADKASNSQRFLAMLAR
NALNRTPPIGFFRTFVLEEDGKHQKTFNLKRRGTAPLSDLIRVHALACGSRAQNSFERLK
AIGNTKLLLDDDLGNLRDALEFISIVRIRHQALAIEADRQPDNNVRPEDLSPFERSHLKD
AFQVVSGAQKFLKFRYHAGVARNV