Protein Info for HP15_3948 in Marinobacter adhaerens HP15

Annotation: periplasmic sensor signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 499 signal peptide" amino acids 1 to 35 (35 residues), see Phobius details transmembrane" amino acids 182 to 205 (24 residues), see Phobius details PF00512: HisKA" amino acids 265 to 332 (68 residues), 63.8 bits, see alignment E=1.2e-21 PF02518: HATPase_c" amino acids 383 to 485 (103 residues), 85.1 bits, see alignment E=4.6e-28

Best Hits

KEGG orthology group: None (inferred from 82% identity to maq:Maqu_1008)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PK02 at UniProt or InterPro

Protein Sequence (499 amino acids)

>HP15_3948 periplasmic sensor signal transduction histidine kinase (Marinobacter adhaerens HP15)
MALSVFRTLYARLAIGLFLLLLVVGGLFTFLSLASVREYSAAVNQQLNRDLARNLVSDRN
LVTDGKLNRDALKQLFELYMTINPSIEIYLLDTEGNILSYSADPNKIKRNRVSLEPVRTL
LENPGAYPLPGDDPRSHDRRKVFSVTPVPSAADPTGYLYVVLRGEEYDLAESMVHSNRLL
QLGAGALAVSLFVGLLAGLVFFRLLTRRLSRLTERVESFERGMSPERAAAVAGKGDDIDY
LAARFDQMAQRIVAQLDLLKHKDAQRRQLVAQVSHDLRTPLASIQGYIEALRMKQDTLAA
EERARFLDVALTESHRLGRLVEELFELAALDAREKQPKTEPFVVAELLHDVVQKHQPEAE
RAGVALSIVSVAPVQVLADIAMTERVLDNLISNAISHSPKDTEITLGVVEQAGGAQITVA
DAGPGIDDEDLEHVFEPFYQAAGASRTGHAGLGLAIAQRMVTLQQGKLSVRNADGAVFSV
WLPLARDSSVAGGEKSTAL