Protein Info for HP15_3926 in Marinobacter adhaerens HP15

Annotation: acyl-CoA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 29 to 408 (380 residues), 303.4 bits, E=2.2e-94
• PF13193: AMP-binding_C
  • amino acids 462 to 539 (78 residues), 64.7 bits, E=1.2e-21

Best Hits

KEGG orthology group: K00666, fatty-acyl-CoA synthase [EC: 6.2.1.-] (inferred from 60% identity to aac:Aaci_0904)

Predicted SEED Role

No annotation

KEGG Metabolic Maps

• Alkaloid biosynthesis II
• Benzoate degradation via CoA ligation
• Biosynthesis of plant hormones
• Caprolactam degradation
• Ethylbenzene degradation
• Geraniol degradation
• Limonene and pinene degradation
• Propanoate metabolism
• Tyrosine metabolism
• alpha-Linolenic acid metabolism

Isozymes

Compare fitness of predicted isozymes for: 6.2.1.-

Use Curated BLAST to search for 6.2.1.-

Sequence Analysis Tools

See E4PJY0 at UniProt or InterPro

Protein Sequence (554 amino acids)

>HP15_3926 acyl-CoA synthetase (Marinobacter adhaerens HP15)
MFDRHYKVWPKELPKTMTLPKTSVYTNLEISARRYPDHTAIIFYDAPITYRRLNEEVETL
AGYLQEQGVKKGDRVLLYMQNSPQYVISYYAILRADAVVIPVNPMNRSAELEHFIADTGA
TVCLAGQELAGFIAPMIGDSNLDQVVVASYSTYIDPETDLDLPAEVAAPVWSRDLPGVVT
WEVAMAAGYAPGPHTATPDDLAVIPYSSGTTGAPKGCMHTHRSVMATAIHRIFWNLTTPD
SVQLATLPFFHVTGMTGSMNGPIAAGAASVIMTRWDRTTASRLIERYKVTGWTNIVTMAV
DFLSNPDIGQYDLSSLNMIGGGGATMPSAVAEKLKRMTGLDYIEGYGLSETMAATHINPN
AHPKSQCLGIPVFDVDSRIIDVDTLEEKGPGETGEIVSCGPQVTRGYWNRPSETEAAFVE
IDGKQFFRTGDLGYYDEDGYFFMVDRVKRMINASGYKVWPSEVEGMMYRHPAIHEVCIIS
APDPKRGETVKACIVLTPEAEGQTSAGDIIAWCKEQMATYKVPTMIDFVDQLPKSPTGKL
MWRALQEEEWKEKS