Protein Info for HP15_3910 in Marinobacter adhaerens HP15

Annotation: metal dependent phosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 374 transmembrane" amino acids 126 to 146 (21 residues), see Phobius details amino acids 158 to 175 (18 residues), see Phobius details PF13487: HD_5" amino acids 143 to 283 (141 residues), 85.5 bits, see alignment E=3.7e-28

Best Hits

KEGG orthology group: None (inferred from 79% identity to maq:Maqu_0258)

Predicted SEED Role

"HD-GYP domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJW4 at UniProt or InterPro

Protein Sequence (374 amino acids)

>HP15_3910 metal dependent phosphohydrolase (Marinobacter adhaerens HP15)
MTELVRIAPGALTIGRPLPWDVYDADGNILLRQGYVIQTDSQLEQLFERGRFKPRKIERP
QEEVFEDTRDRNPFADYPDLLHSLEATLKAITDSDPSAQKRLLGLARMIERTCTESPDAT
LALVHLYSIGPVIYEQILFYAILCQFIGRQFGLEEKRVAVLTTAALTANLALVPIADKLN
ASNTVLNDEQRGVIRKHPERSIQALQAAGIDNKLLLTIIAQHHEQADGSGYPKGLSGTEI
RPEAEILALAERYVAMITKRAYRQRMNVADARKLIANLADGKFRPAIPKALLQILGEYPP
GILVRLENNEVGVVTRRPVRARGPFVKAIFGPRGNRYTGTFERDTSEPDFGIQSLEEPEV
MPSMDFSLVWGFRS