Protein Info for PGA1_78p00310 in Phaeobacter inhibens DSM 17395

Annotation: glycine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 951 PF02347: GDC-P" amino acids 16 to 440 (425 residues), 587.6 bits, see alignment E=1.5e-180 amino acids 472 to 729 (258 residues), 39.2 bits, see alignment E=4.3e-14 TIGR00461: glycine dehydrogenase" amino acids 17 to 940 (924 residues), 1431 bits, see alignment E=0 PF21478: GcvP2_C" amino acids 769 to 890 (122 residues), 195.5 bits, see alignment E=2.3e-62

Best Hits

Swiss-Prot: 76% identical to GCSP_AGRVS: Glycine dehydrogenase (decarboxylating) (gcvP) from Agrobacterium vitis (strain S4 / ATCC BAA-846)

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 76% identity to avi:Avi_2252)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7F2Q4 at UniProt or InterPro

Protein Sequence (951 amino acids)

>PGA1_78p00310 glycine dehydrogenase (Phaeobacter inhibens DSM 17395)
MAFKLTDYEAYDFANRRHIGPSPREMADMLKVIGFNTLDELIDATVPPAIRQTEALDWGP
AMTERDALFHMKEIAGKNKVLTSLIGQGYHGTTTPAPILRNILENPAWYTAYTPYQPEIS
QGRLEALLNFQTMVSDLTGLPVANASLLDEATAAAEAMAMAHRGSRSKANNAAFFVDKNC
HPQTVAVIKTRAEPLGIDVVVAEPTELDAGAVFGAIFQYPGTHGHVTDFSDQIAALHEHK
GIAVVAADILSLALLKSPGEMGADIAIGSTQRFGVPMGYGGPHAAYMATSDKLKRSMPGR
IIGVSIDARGNKAYRLSLQTREQHIRREKANSNVCTAQALLAVIASMYAVYHGPDGIKAI
AQSVHRKTARLAAGLEEAGFKVEPEVFFDTITVEVGHLQKTVMEAAVQRGINLRRVGETK
VGISLDEQTRPETIEAVWGAFGIDRKDDSSNKQYRLPEAMLRDSAYLTHPIFHKNRAEAE
ITRYMRRLADRDLALDRAMIPLGSCTMKLNATIEMIPVTWPEFSNLHPFVPEDQAQGYHQ
MIDDLNDKLCQITGYDAISQQPNSGAQGEYAGLLTIRNYHASRGQAHRNVCLIPTSAHGT
NPASAQMVGWKVVPIKADDNGNIDVADFREKAEKHSDHLAGCMITYPSTHGVFETTVQEV
CQITHDHGGQVYIDGANMNAMVGVSRPGDIGGDVSHLNLHKTFCIPHGGGGPGMGPIGVK
AHLTEHLPGHPEYGTAVGPVSAAPFGSPSILPVSWAYILLMGGSGLTQATKVAILNANYI
AARLQDAYPILYTSESGRVAHECILDTRPLNDEAGVSVDDVAKRLIDSGFHAPTMSWPVA
GTLMVEPTESEPKDELDRFCEAMLSIRSEAQDIIDGKIDAENNPLKHAPHTVRDLVGEWD
RPYSREQACFPPGNLGVDKYWPAVNRVDNAYGDRNLICTCPPMEDYAEAAE