Protein Info for HP15_3771 in Marinobacter adhaerens HP15

Annotation: membrane protein containing cytochrome c oxidase, subunit II domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 359 transmembrane" amino acids 31 to 52 (22 residues), see Phobius details amino acids 73 to 94 (22 residues), see Phobius details PF02790: COX2_TM" amino acids 9 to 90 (82 residues), 48.9 bits, see alignment E=1.2e-16 TIGR02866: cytochrome c oxidase, subunit II" amino acids 23 to 237 (215 residues), 201.7 bits, see alignment E=4.7e-64 PF00116: COX2" amino acids 107 to 228 (122 residues), 133.7 bits, see alignment E=6.4e-43 PF13442: Cytochrome_CBB3" amino acids 261 to 334 (74 residues), 47.5 bits, see alignment E=3.7e-16 PF00034: Cytochrom_C" amino acids 262 to 334 (73 residues), 37 bits, see alignment E=1.4e-12

Best Hits

KEGG orthology group: K02275, cytochrome c oxidase subunit II [EC: 1.9.3.1] (inferred from 91% identity to maq:Maqu_0062)

MetaCyc: 66% identical to cytochrome c oxidase subunit 2 (Pseudomonas putida KT2440)

Predicted SEED Role

"Cytochrome c oxidase polypeptide II (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PI49 at UniProt or InterPro

Protein Sequence (359 amino acids)

>HP15_3771 membrane protein containing cytochrome c oxidase, subunit II domain (Marinobacter adhaerens HP15)
MFPAWSMADWTLNMTPGVTGTSNEIFSLHMTILWICVVIGVVVFGVMFWSIFAHRKSQGA
KPANFHENTLVEILWTIIPFVILVVMAIPATATLVDMYDTSESEVDIKITGYQWKWQYEY
INEDFGYFSNLATPRDQIENRQAKGENYLLEVDNHLVIPVGKKIRFLVTANDVIHSWWVP
DFGVKKDAIPGFINETWTRVDKPGIYRGQCTELCGKDHGFMPVVVEAVPEEEYNTWVAEK
KEAAERERQLTQKDWTMAELMERGEKAYQTACAACHQADGSGAPPAFPALKGSPIATQDM
AAHIDIVVNGKSGTAMQAFGNQLSEVDLAAVITYERNAWGNNTGEMVTPKEIFDYKNQQ