Protein Info for HP15_3732 in Marinobacter adhaerens HP15

Annotation: metallo-beta-lactamase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 302 PF00753: Lactamase_B" amino acids 27 to 215 (189 residues), 56.8 bits, see alignment E=1.5e-19

Best Hits

Swiss-Prot: 50% identical to Y2304_BURP1: Probable metallo-hydrolase BURPS1710b_2304 (BURPS1710b_2304) from Burkholderia pseudomallei (strain 1710b)

KEGG orthology group: None (inferred from 79% identity to csa:Csal_2599)

Predicted SEED Role

"SoxH protein, homolog" in subsystem Sulfur oxidation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PI10 at UniProt or InterPro

Protein Sequence (302 amino acids)

>HP15_3732 metallo-beta-lactamase family protein (Marinobacter adhaerens HP15)
MRTFQQSPAKHAGTPNVAGFFDPRTFSVQYVVSDPETKQCAIIDPVLDYDEKSGATATHH
ADELLAFIREQGFEVQWILDTHPHADHFSAAQYLKEQTGAPTAIGGYVTGVQELWKGIYN
WPDFPADGSQWDHLFRAGDEFRVGNLQGRVMFSPGHTLASVTYVIGDAAFVHDTIFQPDF
GTARADFPGGDAHQLWDSIQAILALPDETRLFTGHDYMPGGREPEWESTVGEQKQANKHL
AETSEAEYVELRNTRDSELPMPKLILHALQVNTRGGRLPEPEANGKRYLKIPLDALEGAA
WE