Protein Info for HP15_3720 in Marinobacter adhaerens HP15

Updated annotation (from data): DNA damage response nuclease
Rationale: Conserved and specific phenotype: important for resisting cisplatin. Contains a VRR-NUC domain that is predicted to have nuclease activity.
Original annotation: protein containing VRR-NUC domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 569 PF21315: FAN1_HTH" amino acids 20 to 102 (83 residues), 97.7 bits, see alignment E=4.5e-32 PF18081: FANC_SAP" amino acids 106 to 160 (55 residues), 24.6 bits, see alignment 3.5e-09 PF08774: VRR_NUC" amino acids 446 to 562 (117 residues), 104.2 bits, see alignment E=7.1e-34

Best Hits

KEGG orthology group: None (inferred from 66% identity to maq:Maqu_0014)

Predicted SEED Role

"Hypothetical protein, restriction endonuclease-like VRR-NUC domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PHZ8 at UniProt or InterPro

Protein Sequence (569 amino acids)

>HP15_3720 DNA damage response nuclease (Marinobacter adhaerens HP15)
MSPAKRQSTQLATADLDNPLYYLENMETVLGWVQSHHGDLLTAEELDRLASFHTLSMPAR
ALLTRMVMRTGDLFRSDKLKYPELGVPEASALDEITEAGWLDTDPLLSLDELFRLFTLGE
LRPAMEPLLKAAGEPANLPKGRMRDALLLRFPDPLIVADWLGQHARPVIRLKTMALFDRV
RLMFFGNLRQSWSDFVLVELGHQQFEPVTFTPDSRAFQQRSEVDLYLAMHQCREWLDQGV
PALEVWQAVPSPSNNAWLTSRRDRLLLELGRQAERQGERELALEAFASSGHREARLKQLR
LLERMKRHREAWAIASEWQNQELSDAEAQGLARILKRLASRLGEIAPPPPEQPLIREITL
TLPKPEVGSVEYAVRDHLYRDEAPVLYVENTLINGLFGLLCWQTIFEPVPGAFFHPFHVG
PADLTREDFVSRRKGSFEQCFARLADGSYRERILANYRAKQGTTNPFVIWPVITEELLSL
ALDCLPPPDLERLFRRLLLNIREHRSGFPDLIRFLPNVAEPDKRYEMIEVKGPGDRLQDH
QIRWLEFFAAEGIPASVCYVRWQASEAME