Protein Info for HP15_3708 in Marinobacter adhaerens HP15
Annotation: 4-aminobutyrate aminotransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 50% identical to DAVT_PSEPK: 5-aminovalerate aminotransferase DavT (davT) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
KEGG orthology group: K07250, 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC: 2.6.1.19 2.6.1.22] (inferred from 89% identity to maq:Maqu_0007)MetaCyc: 50% identical to 5-aminovalerate aminotransferase (Pseudomonas aeruginosa)
5-aminovalerate transaminase. [EC: 2.6.1.48]
Predicted SEED Role
"Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)" (EC 2.6.1.19)
MetaCyc Pathways
- L-valine degradation I (7/8 steps found)
- L-lysine degradation X (5/6 steps found)
- 4-aminobutanoate degradation III (2/2 steps found)
- GABA shunt II (3/4 steps found)
- 4-aminobutanoate degradation I (1/2 steps found)
- 4-aminobutanoate degradation II (1/2 steps found)
- L-lysine degradation IV (3/5 steps found)
- GABA shunt I (2/4 steps found)
- L-lysine degradation I (4/7 steps found)
- superpathway of 4-aminobutanoate degradation (1/3 steps found)
- L-lysine degradation III (2/6 steps found)
- superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
- 4-aminobutanoate degradation V (2/7 steps found)
- nicotine degradation I (pyridine pathway) (4/17 steps found)
- superpathway of L-lysine degradation (12/43 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Butanoate metabolism
- Glutamate metabolism
- Lysine degradation
- Propanoate metabolism
- Valine, leucine and isoleucine degradation
- beta-Alanine metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.6.1.19 or 2.6.1.22 or 2.6.1.48
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See E4PHH1 at UniProt or InterPro
Protein Sequence (425 amino acids)
>HP15_3708 4-aminobutyrate aminotransferase (Marinobacter adhaerens HP15) MSNKELQALKERYVAAGAASPNEQFADHATNAELWDADGKRMIDFAGGIGVLNIGHRHPK VVEAVKAQLDKLMHTCQTVMPYEGYVKLAEKLSGVVPVRGHAKVMLANSGAEALENAMKI ARAATGKTNVICFDGGYHGRTFYTMAMNGKAAPYQTDFGPMPGTVYRAPYPVPYHGVSED EALRGLKMAMKADSPAHNTAAIVIEPVLGEGGFYAAPTSFLKEIRKICDENDILMIADEV QSGFGRTGKMFAIEHSGVEPDLMTMAKSMADGMPISAIVGTDKYMDASGPNSLGGTYTGS PTACAAALAVFDVFKEEDILGKSQALGEKLKQRFSQWQEQFAHVDNVRNLGPMAAFELVE SKESRTPKPELAAAVTKKAKEKGLILLSCGMYGNTLRFLMPVTIEDEVLEEGLAIVEESL KEVGA