Protein Info for HP15_3696 in Marinobacter adhaerens HP15

Annotation: acyl-CoA dehydrogenase domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 689 PF12418: AcylCoA_DH_N" amino acids 87 to 111 (25 residues), 33.5 bits, see alignment (E = 8.4e-12) PF02771: Acyl-CoA_dh_N" amino acids 129 to 240 (112 residues), 50.4 bits, see alignment E=7.1e-17 PF02770: Acyl-CoA_dh_M" amino acids 246 to 355 (110 residues), 55.2 bits, see alignment E=1.6e-18 PF00441: Acyl-CoA_dh_1" amino acids 365 to 536 (172 residues), 73.2 bits, see alignment E=6.9e-24 PF12806: Acyl-CoA_dh_C" amino acids 558 to 681 (124 residues), 100.6 bits, see alignment E=1.8e-32

Best Hits

KEGG orthology group: K00257, [EC: 1.3.99.-] (inferred from 87% identity to maq:Maqu_3891)

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.7)" (EC 1.3.8.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7, 1.3.99.-

Use Curated BLAST to search for 1.3.8.7 or 1.3.99.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PHF9 at UniProt or InterPro

Protein Sequence (689 amino acids)

>HP15_3696 acyl-CoA dehydrogenase domain protein (Marinobacter adhaerens HP15)
MTFTLSEQENVGVLGARKYAETLFSDHYPESTISATSSRPIVHSDSLPGAFRQWQCPGIG
VKHKATNGGCPPKIVEKDTEDSAMPVYKAPLRDMKFLLNEVFDYPGHYATLTSGENATPD
IVDAILGECGKFCEEVLSPLYLSGDEEGCKLDNGEVTTPAGYRDAYQQYAMGGWQGLSAP
EEYGGQGLPASMGLLKQEMMGTANWPFSMYPGLSLGAMNTIFLHGTEDQKQTYLAPLTEG
RWAGTMCLTEPQCGTDLGQVKTKAEPQADGSYRLTGTKIFISSGDHDLTENIVHIVLARL
PDAPKGTRGISLFIVPKFLPDSNGDVGERNGVVCGSLEKKMGIKASATCVLNFDGATGFL
IGPENDGLNCMFTFMNTARIGTAIQGVGPAELSYQWALAYAKDRRSMRALSGKKEPDQVA
DSLIHHADVRRMLLTQKAIAEGGRAMLYYAARLADHMVEGFTEGDEKKADKYDDKLGFLT
PILKGFLTELGCEAANLGVQVFGGHGYIREHGMEQIVRDTRIATLYEGTTGIQALDLLGR
KVLLMTQGGAVREFTLNIANFARKHLTDKRLRPWALELLKLTGQWNLLTVRIMLAARKDR
DVVSSASYDFLMYSGYVTMAYIWLRQAAVAVDKLDNGGEESTGFYQAKLATTEFYFERLL
PRAQSHATSMLSPSKNLMQLDAEDLAFTG