Protein Info for PGA1_262p01550 in Phaeobacter inhibens DSM 17395

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 590 PF02771: Acyl-CoA_dh_N" amino acids 38 to 155 (118 residues), 43.5 bits, see alignment E=7.4e-15 PF02770: Acyl-CoA_dh_M" amino acids 161 to 270 (110 residues), 48.1 bits, see alignment E=2.2e-16 PF00441: Acyl-CoA_dh_1" amino acids 280 to 445 (166 residues), 98.2 bits, see alignment E=1.1e-31 PF12806: Acyl-CoA_dh_C" amino acids 463 to 585 (123 residues), 93.9 bits, see alignment E=1.7e-30

Best Hits

Swiss-Prot: 69% identical to DMDC_RUEPO: 3-methylmercaptopropionyl-CoA dehydrogenase (dmdC) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

KEGG orthology group: None (inferred from 69% identity to sil:SPO3804)

MetaCyc: 69% identical to 3-(methylsulfanyl)propanoyl-CoA dehydrogenase monomer (Ruegeria pomeroyi DSS-3)
RXN-12572 [EC: 1.3.99.41]

Predicted SEED Role

"3-methylmercaptopropionyl-CoA dehydrogenase (DmdC)"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.99.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DWM4 at UniProt or InterPro

Protein Sequence (590 amino acids)

>PGA1_262p01550 acyl-CoA dehydrogenase (Phaeobacter inhibens DSM 17395)
MTYEAPIRDMMFNLDHLSQWPQVSALEKYGEIDRTDARAALEELGRFCTDLIAPLSAVGD
TTGARLDGDKVVLPEAFAAAYAQFVDMGWQSLAHPVDHGGMGLPRVVGAAATEILNAADM
SFGLCPLLTDGAIDALQLSGTEAQKELYLRPLVSGRWTGTMNLTEPQAGSDLGRVRCKAE
PRADGSYGVSGTKIFITYGAHELSENIIHLVLARTPGAPDGHRGLSLFLVPKFLVDQDGT
PGDRNSVNCVSIEHKLGVRASPTAVLEYDNATGYLIGEENRGLEYMFTMMNAARFAVGVQ
GVAVSERAYQHALSYAKERVQGQAIGLAPDKTTAIIGHPDVRRMVLRMRALVEGGRSLSM
AAAGWLDLSQNGDDDIRAETAPVAEFLVPLVKAFCSERAVEVASLGVQIHGGMGFIEETG
VAQFYRDARILPIYEGTTAIQANDLLGRKVLRDAGQTARRFSAMIADTEAALQTGSAKLQ
DIAARLGEARAAFDASLAWLLETAPNDPRAAFGGSVPFLNLTGTLAAGWQLARGARAAEA
ELQRGNETDFMAQKITTVQIFAHHILVECESDRARIMTGATSLLDEASQV