Protein Info for Psest_3806 in Pseudomonas stutzeri RCH2

Annotation: Phosphomannomutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 407 to 536 (130 residues), 126.1 bits, E=1.7e-40
• PF02879: PGM_PMM_II
  • amino acids 552 to 649 (98 residues), 100.8 bits, E=1.2e-32
• PF02880: PGM_PMM_III
  • amino acids 655 to 759 (105 residues), 79.6 bits, E=4.1e-26
• PF00408: PGM_PMM_IV
  • amino acids 769 to 846 (78 residues), 55.7 bits, E=8.3e-19

Best Hits

KEGG orthology group: K01835, phosphoglucomutase [EC: 5.4.2.2] K01840, phosphomannomutase [EC: 5.4.2.8] (inferred from 91% identity to psa:PST_0470)

Predicted SEED Role

"Phosphomannomutase (EC 5.4.2.8) / Phosphoglucomutase (EC 5.4.2.2)" in subsystem Alginate metabolism or Mannose Metabolism (EC 5.4.2.2, EC 5.4.2.8)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (11/11 steps found)
• colanic acid building blocks biosynthesis (10/11 steps found)
• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• superpathway of anaerobic sucrose degradation (15/19 steps found)
• glycogen degradation I (7/8 steps found)
• GDP-mannose biosynthesis (4/4 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• glucose and glucose-1-phosphate degradation (4/5 steps found)
• sucrose biosynthesis II (6/8 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (3/4 steps found)
• starch degradation V (3/4 steps found)
• β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (2/3 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• glycogen degradation II (4/6 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• chitin biosynthesis (6/9 steps found)
• sucrose degradation II (sucrose synthase) (3/5 steps found)
• starch degradation III (2/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (2/4 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (9/14 steps found)
• D-galactose degradation I (Leloir pathway) (2/5 steps found)
• glucosylglycerol biosynthesis (2/5 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (4/8 steps found)
• starch biosynthesis (5/10 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (1/5 steps found)
• β-(1,4)-mannan degradation (2/7 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (7/19 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (14/33 steps found)
• streptomycin biosynthesis (1/18 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism
• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Nucleotide sugars metabolism
• Pentose phosphate pathway
• Starch and sucrose metabolism
• Streptomycin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.2

Use Curated BLAST to search for 5.4.2.2 or 5.4.2.8

Sequence Analysis Tools

See L0GQI4 at UniProt or InterPro

Protein Sequence (857 amino acids)

>Psest_3806 Phosphomannomutase (Pseudomonas stutzeri RCH2)
MALFKRTAKDSGVLNPASTRTKPAGVTIKPLLGGLASGLIGLGAAAALLWLGLQNAQQQQ
QAQLSQAWGQSQAGALQQALRQQRAETQALVDRQQLADVLRGDAERRRDAEERLLQLPGV
VDAHLNIRGRAVPDTNRPGPLNFAALDLLQRVEAGQSPAPEAYKVDNRWLLYSAVPLRAE
GQQAIRGTLLLVSDLERLFATLPALPAEAGQLRLTQQFSGTQEQLLLQRGAPAEGATAVT
LSSGNANWKLVYLPGSEAAQATLSPLLLIGAALLALAGMLIGLQLVLGSQQRKLREDVMQ
ISRLLQELSTGKTIQVPALSLPVLDALARNMVRLPVRPAGPAPTQAPAAAPAVRPAKPTE
YVDPRLPETDILDIDILDEDQDIFGLDTKERETAMSSAKAPNLPASIFRAYDIRGVVGDS
LTTETAYWVGRAIGSESLAKGEPNVSVGRDGRLSGPELVQHLIQGLLDSGCDVSDIGMVP
TPVLYYAANILAGKSGVMLTGSHNPPDYNGFKIVIAGDTLANEQIQTLRKRIENNDLSSG
VGKVEQVDVLERYFQQIRSDIAMAKPMKVVVDCGNGVAGVIAPRMIEALGCTVIPLYCDV
DGNFPNHHPDPGKPENLVDLIAKVKSEKADLGLAFDGDGDRVGVVTNAGTMIYADRLLML
FAKDVVSRNPGADIIFDVKCTRRLTPLISGYGGRPVMWKTGHSLIKKKMKESGALLAGEM
SGHIFFKERWFGFDDGIYSAARLLEILSQDKRDAEQVFAAFPCDISTPEINITVTEESKF
TIMDALQRDAQWGEANLITLDGVRVDYPKGWGLIRASNTTPVLVLRFEADSEEELSRIQD
VFRAQLLNVAPDLKLPF