Protein Info for HP15_3668 in Marinobacter adhaerens HP15

Annotation: sodium/proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 501 transmembrane" amino acids 20 to 39 (20 residues), see Phobius details amino acids 46 to 66 (21 residues), see Phobius details amino acids 86 to 109 (24 residues), see Phobius details amino acids 121 to 143 (23 residues), see Phobius details amino acids 148 to 166 (19 residues), see Phobius details amino acids 201 to 223 (23 residues), see Phobius details amino acids 242 to 264 (23 residues), see Phobius details amino acids 301 to 319 (19 residues), see Phobius details amino acids 325 to 342 (18 residues), see Phobius details amino acids 354 to 373 (20 residues), see Phobius details amino acids 395 to 417 (23 residues), see Phobius details amino acids 456 to 473 (18 residues), see Phobius details amino acids 479 to 498 (20 residues), see Phobius details PF06450: NhaB" amino acids 1 to 498 (498 residues), 765.6 bits, see alignment E=3e-234 PF03600: CitMHS" amino acids 71 to 334 (264 residues), 59.4 bits, see alignment E=3.4e-20

Best Hits

Swiss-Prot: 92% identical to NHAB_MARHV: Na(+)/H(+) antiporter NhaB (nhaB) from Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)

KEGG orthology group: K03314, Na+:H+ antiporter, NhaB family (inferred from 92% identity to maq:Maqu_3871)

MetaCyc: 64% identical to Na+:H+ antiporter NhaB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-130

Predicted SEED Role

"Na+/H+ antiporter NhaB" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PHD1 at UniProt or InterPro

Protein Sequence (501 amino acids)

>HP15_3668 sodium/proton antiporter (Marinobacter adhaerens HP15)
MPTTVISGFTHNFLGKAPVWYKQVILLFLVANPIVMWTLGPGTAGWLLIAEFIFTLAMAL
KCYPLLPGGLLAVEALLIGLTTPDAVYLEVLTNFPVILLLMFMVAGIYFMKELLLVTFTQ
ILVGVRSKSALSLLFCSAAALLSAFLDALTVTAVIISVAVGFYAVYHKVASGKGYQHKDH
NAGSDDEVIELHREDLENFRAFLRSLLMHGAIGTALGGVATMVGEPQNLLIAKVVGWDFA
GFFLHMAPVSLPVLAAGLFTCWALEKLRWFGYGGRLPKPVRQVLEEFAENERTKRTKADQ
AALWVQAVAAAILVVGLAFHLAEVGLIGLLVIILITSFTGVTDEHQIGKAFQESLPFTSL
LVVFFAVVAVIHEQHLFKPIIDYVLSLPEARQPGMFFIANGVLSMISDNVFVATVYISEV
KQALDAGAISYEHFQKLAVAINTGTNLPSVATPNGQAAFLFLLTSAIAPLVRLSYGKMVV
MAFPYMLVMGGVGLYMVMNYI