Protein Info for PGA1_262p00440 in Phaeobacter inhibens DSM 17395

Updated annotation (from data): glucose transporter, permease component
Rationale: specific phenotype on glucose and cofit with nearby xylF (PGA1_262p00430) and xylG (PGA1_262p00450). This is similar to the gxyB (Atu3575) of Agrobacterium tumefaciens, which is involved in the transport of glucose, glucosamine, and xylose (PMCID: PMC4135649). It is not clear if the Phaeobacter system transports xylose, as it is not required for utilizing xylose, but no other xylose transport system was identified either.
Original annotation: xylose transport system permease protein XylH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 433 transmembrane" amino acids 25 to 44 (20 residues), see Phobius details amino acids 56 to 77 (22 residues), see Phobius details amino acids 83 to 104 (22 residues), see Phobius details amino acids 116 to 135 (20 residues), see Phobius details amino acids 139 to 165 (27 residues), see Phobius details amino acids 178 to 209 (32 residues), see Phobius details amino acids 229 to 250 (22 residues), see Phobius details amino acids 270 to 295 (26 residues), see Phobius details amino acids 326 to 348 (23 residues), see Phobius details amino acids 360 to 389 (30 residues), see Phobius details amino acids 405 to 425 (21 residues), see Phobius details PF02653: BPD_transp_2" amino acids 54 to 419 (366 residues), 113.7 bits, see alignment E=4.5e-37

Best Hits

KEGG orthology group: K10544, D-xylose transport system permease protein (inferred from 85% identity to sit:TM1040_3175)

Predicted SEED Role

"Xylose ABC transporter, permease protein XylH" in subsystem Xylose utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DWB0 at UniProt or InterPro

Protein Sequence (433 amino acids)

>PGA1_262p00440 glucose transporter, permease component (Phaeobacter inhibens DSM 17395)
MTETTSQPIPEHSKRGLFQQLELDVRLLGMIGAFVILCIGFNILTDGRFLTPRNIFNLTI
QTVSVAIMATGMVFVIVTRHIDLSVGALLATCSAVMAVVQTDVLPDMFGLGLNHPATWII
TVAVGLAIGTLIGAFQGWMVGFLTIPAFIVTLGGFLVWRNVAWYLTDGQTIGPLDSTFLV
FGGTSGTLGTTLSWVVGIVATLLALAALWNSRRAKQGHGFPVKPAWAEAVIAGSIAASIL
GFVAILNAYQIPARRLKRMMEAQGETMPEGLVVGYGLPISVLILIATAVVMTIIARRTRL
GRYIFATGGNPDAAELSGINTRLLTVKIFALMGFLCALSAVVASARLANHSNDIGTLDEL
RVIAAAVIGGTALSGGFGTIYGAILGALIMQSLQSGMAMVGVDAPFQNIVVGTVLVAAVW
IDILYRKRVGARI