Protein Info for PGA1_262p00230 in Phaeobacter inhibens DSM 17395
Annotation: betaine aldehyde dehydrogenase BetB
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 40% identical to BETB_XANC8: NAD/NADP-dependent betaine aldehyde dehydrogenase (betB) from Xanthomonas campestris pv. campestris (strain 8004)
KEGG orthology group: K00130, betaine-aldehyde dehydrogenase [EC: 1.2.1.8] (inferred from 80% identity to sit:TM1040_0847)MetaCyc: 40% identical to aldehyde dehydrogenase, E3 isozyme (Homo sapiens)
4-trimethylammoniobutyraldehyde dehydrogenase. [EC: 1.2.1.47]; Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.47, 1.2.1.3]; 1.2.1.3 [EC: 1.2.1.47, 1.2.1.3]; Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.47, 1.2.1.3, 1.2.1.19]
Predicted SEED Role
"Aldehyde dehydrogenase (EC 1.2.1.3)" in subsystem Entner-Doudoroff Pathway or Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 1.2.1.3)
MetaCyc Pathways
- choline-O-sulfate degradation (3/3 steps found)
- ethanol degradation II (3/3 steps found)
- ethanol degradation IV (3/3 steps found)
- hypotaurine degradation (3/3 steps found)
- choline degradation I (2/2 steps found)
- glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
- glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
- putrescine degradation V (2/2 steps found)
- phytol degradation (3/4 steps found)
- ethanol degradation III (2/3 steps found)
- glycine betaine biosynthesis III (plants) (2/3 steps found)
- putrescine degradation IV (2/3 steps found)
- β-alanine biosynthesis I (1/2 steps found)
- β-alanine biosynthesis IV (1/2 steps found)
- ethylene glycol degradation (1/2 steps found)
- putrescine degradation I (1/2 steps found)
- octane oxidation (3/5 steps found)
- D-arabinose degradation II (2/4 steps found)
- L-carnitine biosynthesis (2/4 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (2/4 steps found)
- choline degradation IV (2/4 steps found)
- fatty acid α-oxidation I (plants) (2/4 steps found)
- superpathway of glycol metabolism and degradation (4/7 steps found)
- dimethylsulfoniopropanoate biosynthesis I (Wollastonia) (1/3 steps found)
- histamine degradation (1/3 steps found)
- 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
- L-lysine degradation X (3/6 steps found)
- mitochondrial NADPH production (yeast) (2/5 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (4/8 steps found)
- dimethylsulfoniopropanoate biosynthesis II (Spartina) (1/4 steps found)
- putrescine degradation III (1/4 steps found)
- serotonin degradation (3/7 steps found)
- superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
- Entner-Doudoroff pathway II (non-phosphorylative) (4/9 steps found)
- dopamine degradation (1/5 steps found)
- superpathway of ornithine degradation (3/8 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
- L-lysine degradation I (2/7 steps found)
- ceramide degradation by α-oxidation (2/7 steps found)
- sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
- alkane oxidation (1/6 steps found)
- limonene degradation IV (anaerobic) (1/7 steps found)
- aromatic biogenic amine degradation (bacteria) (1/8 steps found)
- noradrenaline and adrenaline degradation (4/13 steps found)
- ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)
- superpathway of pentose and pentitol degradation (11/42 steps found)
- superpathway of L-lysine degradation (10/43 steps found)
KEGG Metabolic Maps
- 1,2-Dichloroethane degradation
- 3-Chloroacrylic acid degradation
- Arginine and proline metabolism
- Ascorbate and aldarate metabolism
- Butanoate metabolism
- Fatty acid metabolism
- Glycerolipid metabolism
- Glycine, serine and threonine metabolism
- Glycolysis / Gluconeogenesis
- Histidine metabolism
- Limonene and pinene degradation
- Lysine degradation
- Propanoate metabolism
- Pyruvate metabolism
- Tryptophan metabolism
- Urea cycle and metabolism of amino groups
- Valine, leucine and isoleucine degradation
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.3, 1.2.1.8
Use Curated BLAST to search for 1.2.1.19 or 1.2.1.3 or 1.2.1.47 or 1.2.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See I7F4E7 at UniProt or InterPro
Protein Sequence (494 amino acids)
>PGA1_262p00230 betaine aldehyde dehydrogenase BetB (Phaeobacter inhibens DSM 17395) MSVDGLIAAYFDTGALPDLPRDHFIDGRAVAPGAGGRMESFDPGRGTAFDDFAAGDAADV DHAVTSAVAGFEIWSATPPARRCAILNEAARLMRHEAEHLAVVECVDSGKTLAEARGDIA GSARLLEYYAGAADKLDGRSVNLGNDNAAFTLREPVGVTAHIVPWNYPSSTLVRGIAPAL AAGCSAVVKPAETTPFTALMIADLLIRAGLPAGVVNVVTGTGIAAGAPLVRDPRVRHVTF TGSVATGVGVMQSVAPNVTGLTLELGGKSPLVAFGDANVDAVVEGALWAIFSNAGQICSA GSRLVIHRSLHAEVRDKLVARAQRLRVGHGLRGPDIGAVNSARHLAQIDDHVSRARTRGV EIVTGGEILTDVESGKGWFYAPTILDDLAANDDAVLQEIFGPVLAIQVFEDEAEALALAN GTEFALAAGIYTRDIATALRMARRVDAGQVTVNDYWAGGIELPFGGNRKSGFGREKGLEG LDAYTRSKAVTLAV