Protein Info for HP15_358 in Marinobacter adhaerens HP15

Annotation: tyrosyl-tRNA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 403 TIGR00234: tyrosine--tRNA ligase" amino acids 7 to 399 (393 residues), 377.2 bits, see alignment E=5.6e-117 PF00579: tRNA-synt_1b" amino acids 33 to 314 (282 residues), 278.6 bits, see alignment E=3.1e-87

Best Hits

Swiss-Prot: 74% identical to SYY_HAHCH: Tyrosine--tRNA ligase (tyrS) from Hahella chejuensis (strain KCTC 2396)

KEGG orthology group: K01866, tyrosyl-tRNA synthetase [EC: 6.1.1.1] (inferred from 87% identity to maq:Maqu_0697)

Predicted SEED Role

"Tyrosyl-tRNA synthetase (EC 6.1.1.1)" (EC 6.1.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PLW6 at UniProt or InterPro

Protein Sequence (403 amino acids)

>HP15_358 tyrosyl-tRNA synthetase (Marinobacter adhaerens HP15)
MLFMASIDEALAIIKRGVDELIPEDELIEKLKEGRPLRIKAGFDPTAPDLHLGHTVLINK
LRQFQDLGHEVMFLIGDFTGMIGDPTGKSATRPPLTEQQVAENAVSYKEQVFKILDPAKT
RVMFNSDWMGKMSAADMIKLAGQYTVARMLERDDFTKRYRAEQAIAIHEFLYPLVQGYDS
VAMEADVELGGTDQKFNLLMGRILQKHYGQSPQVILTMPILEGLDGVQKMSKSLGNYVGV
NDSPGEMYTKLLSMPDDLLWRYFELLSFRPLAEVDEFRKAVAGGANPPGLKKLLAEEIIT
RFHDEEAARTAHKSAGNRVALGEIPDNVPTVEVPLEGQSEIPMAAVLRLAGLVKNGAAAR
DVLGRGAVFVDGQKFEGDRMFVEGDDCVIQAGKKKIARVLITV