Protein Info for Psest_3648 in Pseudomonas stutzeri RCH2
Annotation: anthranilate phosphoribosyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 97% identical to TRPD_PSEU5: Anthranilate phosphoribosyltransferase (trpD) from Pseudomonas stutzeri (strain A1501)
KEGG orthology group: K00766, anthranilate phosphoribosyltransferase [EC: 2.4.2.18] (inferred from 97% identity to psa:PST_0746)Predicted SEED Role
"Anthranilate phosphoribosyltransferase (EC 2.4.2.18)" in subsystem Auxin biosynthesis or Tryptophan synthesis (EC 2.4.2.18)
MetaCyc Pathways
- superpathway of aromatic amino acid biosynthesis (18/18 steps found)
- superpathway of L-tryptophan biosynthesis (13/13 steps found)
- superpathway of chorismate metabolism (44/59 steps found)
- L-tryptophan biosynthesis (6/6 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Phenylalanine, tyrosine and tryptophan biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 2.4.2.18
Use Curated BLAST to search for 2.4.2.18
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0GQ48 at UniProt or InterPro
Protein Sequence (348 amino acids)
>Psest_3648 anthranilate phosphoribosyltransferase (Pseudomonas stutzeri RCH2) MDIKEALNRIVGQLDLSTEEMQAVMRQIMTGQCTDAQVGAFLMGMRMKSETIDEIVGAVQ VMRELAAPVRFDTDKLVDTCGTGGDGMNIFNVSTAASFVVAAAGGKVAKHGNRAVSGKSG SADLLEAAGVFLDLTPEQVARSVDTVGVGFMFAPAHHGAMKHAAGPRRELGLRTLFNILG PMANPAGVRHQVLGVFSKALCRPMAEVLARLGSKHVLVVHAQDGLDEISLAAPTHVAELK DGEIREYSIQPEDFGIKSQSLIGLNVEDAQGSLALIRDALGRRQSENGQKAADMIVLNAG AALYAADLASSLKQGVEMAHDALSTGLARDKLEELVSFTAVFKQENQK