Protein Info for HP15_3519 in Marinobacter adhaerens HP15

Annotation: CheB methylesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 PF01339: CheB_methylest" amino acids 156 to 331 (176 residues), 138.7 bits, see alignment E=8.5e-45

Best Hits

KEGG orthology group: K06597, chemosensory pili system protein ChpB (putative protein-glutamate methylesterase) (inferred from 83% identity to maq:Maqu_3773)

Predicted SEED Role

"Chemotaxis response regulator protein-glutamate methylesterase CheB (EC 3.1.1.61)" in subsystem Bacterial Chemotaxis (EC 3.1.1.61)

Isozymes

Compare fitness of predicted isozymes for: 3.1.1.61

Use Curated BLAST to search for 3.1.1.61

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PG19 at UniProt or InterPro

Protein Sequence (350 amino acids)

>HP15_3519 CheB methylesterase (Marinobacter adhaerens HP15)
MAGQTGRPRVGIVSDVVLQRHRLQAATSKFGLEVRFAGDPERLLGYPEFPDASLWLVTLE
DEADHPLLFDHLLENTDAPVLFGLDEAPKPGSTEYFRWERRLLGKLEQQLGHLEELDSEA
TLAELEQETPAPAPSPGLPHWITPAVPGSVAEEVWILGASLGGPAAVKTFLDHLPPNLPV
GFIYAQHIDGNFTEVLTRVLGRHAHYQLKRAEEGYRVKNGDVVLMPVEHEWKLSEQGALT
ETSNAWPGPYGPSIDQVLLNVADHYGQRCHAILFSGMGNDGAIAAPLLKAYGSRIWVQES
TSCGNSSMPESVAATGCSGFCGTPEQLARELVKTIEESCLLKSRQKRDSA