Protein Info for HP15_3505 in Marinobacter adhaerens HP15

Annotation: RND type efflux pump involved in aminoglycoside resistance (AdeT)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 321 PF19582: AdeT1_2" amino acids 40 to 316 (277 residues), 269.6 bits, see alignment E=2.2e-84

Best Hits

Swiss-Prot: 40% identical to ADET1_ACIBA: Probable solute-binding protein AdeT1 (adeT1) from Acinetobacter baumannii

KEGG orthology group: None (inferred from 89% identity to maq:Maqu_3759)

Predicted SEED Role

"FIG00785090: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PG05 at UniProt or InterPro

Protein Sequence (321 amino acids)

>HP15_3505 RND type efflux pump involved in aminoglycoside resistance (AdeT) (Marinobacter adhaerens HP15)
MGQAQAQNEPLERSFCVFDPVGANGPLFAITKTFQPVALKNGIKLDLRAYTDEKVAAEDF
KAGQCDAVLLTGTRAREFNKFTGSLEAMGAVPGEEEMRLLYNTLSQPKARRFLIDGPYEV
AGVFPGGAIYLHTRDRNIDSVEKLQGKRIATLDYDQASVRMVRHVGASVVGSNSANFAGK
FNNGSVDLAYAPAVAYTPLELYKGVQPNGAVVKYALGYMNFQVIIHRDRFPDSAGQMVRD
QAIKRIDEAYEIIAQAEAEIPEDVWMQLPQEDTAEYDKMLRKVRLSLLEDGVYDERAIKL
MKAIRCRVDATRSECASVAGT