Protein Info for PGA1_c36120 in Phaeobacter inhibens DSM 17395

Annotation: putative glutathione S-transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02798: GST_N
  • amino acids 3 to 71 (69 residues), 48.6 bits, E=2.6e-16
• PF13417: GST_N_3
  • amino acids 4 to 77 (74 residues), 75.1 bits, E=1.3e-24
• PF13409: GST_N_2
  • amino acids 10 to 73 (64 residues), 68 bits, E=2.7e-22
• PF14497: GST_C_3
  • amino acids 134 to 199 (66 residues), 23.8 bits, E=1.3e-08

Best Hits

Swiss-Prot: 47% identical to FZLA_CAUVN: FtsZ-localized protein A (fzlA) from Caulobacter vibrioides (strain NA1000 / CB15N)

KEGG orthology group: K00799, glutathione S-transferase [EC: 2.5.1.18] (inferred from 90% identity to sit:TM1040_2825)

Predicted SEED Role

"Glutathione S-transferase family protein" in subsystem Glutathione: Non-redox reactions

MetaCyc Pathways

• 4-hydroxy-2-nonenal detoxification (1/4 steps found)
• glutathione-mediated detoxification I (3/8 steps found)
• pentachlorophenol degradation (3/10 steps found)
• gliotoxin biosynthesis (2/9 steps found)
• glutathione-mediated detoxification II (1/9 steps found)
• indole glucosinolate activation (intact plant cell) (3/12 steps found)
• camalexin biosynthesis (2/12 steps found)

KEGG Metabolic Maps

• Drug metabolism - cytochrome P450
• Glutathione metabolism
• Metabolism of xenobiotics by cytochrome P450

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.18

Use Curated BLAST to search for 2.5.1.18

Sequence Analysis Tools

See I7E5X8 at UniProt or InterPro

Protein Sequence (221 amino acids)

>PGA1_c36120 putative glutathione S-transferase (Phaeobacter inhibens DSM 17395)
MARLYHVPLSPFCRKVRLSLAEKRIEVELVEERYWEKEADFLRRNPAAKVPVIRLDGKLM
AESAAICEYLEETRPDPSLMPSDPEGRYEVRRLVSWFDDKFHHEVTSKLLYERVNKKVTG
QGYPDSGNVKAGARAIKYHLDYLAWLLDHRRWLAGDQMTLADFAAAAHLSSLDYISDVDW
NRSAVVKDWYAKIKSRPAFRSILADQIPGFSPPAHYADLDF