Protein Info for PGA1_c35980 in Phaeobacter inhibens DSM 17395

Annotation: lipopolysaccharide export system ATP-binding protein LptB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 252 TIGR04406: LPS export ABC transporter ATP-binding protein" amino acids 15 to 250 (236 residues), 359.9 bits, see alignment E=2.7e-112 PF00005: ABC_tran" amino acids 31 to 176 (146 residues), 122.6 bits, see alignment E=2.8e-39 PF12399: BCA_ABC_TP_C" amino acids 224 to 248 (25 residues), 30.8 bits, see alignment (E = 2.7e-11)

Best Hits

Swiss-Prot: 62% identical to Y3926_AZOC5: Probable ABC transporter ATP-binding protein AZC_3926 (AZC_3926) from Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)

KEGG orthology group: K06861, lipopolysaccharide export system ATP-binding protein [EC: 3.6.3.-] (inferred from 90% identity to sit:TM1040_0024)

MetaCyc: 61% identical to lipopolysaccharide transport system ATP-binding protein (Brucella abortus 2308)
TRANS-RXN2B4Q-128 [EC: 7.5.2.5]

Predicted SEED Role

"Lipopolysaccharide ABC transporter, ATP-binding protein LptB" in subsystem KDO2-Lipid A biosynthesis

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-

Use Curated BLAST to search for 3.6.3.- or 7.5.2.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7ES87 at UniProt or InterPro

Protein Sequence (252 amino acids)

>PGA1_c35980 lipopolysaccharide export system ATP-binding protein LptB (Phaeobacter inhibens DSM 17395)
MAKPELTVTSGSSGLRIEKLRKSYSKKVVIRDVSMSLDRGEVVALLGPNGSGKTTSFYAI
AGLVFPEAGSVTIDGQNATTLPMYRRARMGIGYLPQEMSIFRGLSVEDNISSVLDIAVKH
AHKRRERLEELLSDFSIEHLRRAPALALSGGERRRVEIARCLAADPKYLLLDEPFAGVDP
ISVGDIRHLVGDLKKRGIGVLITDHNVRETLEIVDRAYILHDGKVLMSGTPAEVVDNENV
RRVYLGDNFRIS