Protein Info for HP15_3466 in Marinobacter adhaerens HP15

Annotation: two component, sigma54 specific, transcriptional regulator, Fis family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 523 PF01590: GAF" amino acids 21 to 137 (117 residues), 23.1 bits, see alignment E=2.8e-08 PF00158: Sigma54_activat" amino acids 196 to 362 (167 residues), 225.7 bits, see alignment E=8.4e-71 PF14532: Sigma54_activ_2" amino acids 197 to 367 (171 residues), 88.2 bits, see alignment E=1.9e-28 PF07728: AAA_5" amino acids 220 to 339 (120 residues), 34.5 bits, see alignment E=6.1e-12 PF02954: HTH_8" amino acids 480 to 518 (39 residues), 28.2 bits, see alignment 3.9e-10

Best Hits

KEGG orthology group: K11908, sigma-54 specific transcriptional regulator (inferred from 86% identity to maq:Maqu_3723)

Predicted SEED Role

"Sigma-54 dependent transcriptional regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PFF9 at UniProt or InterPro

Protein Sequence (523 amino acids)

>HP15_3466 two component, sigma54 specific, transcriptional regulator, Fis family (Marinobacter adhaerens HP15)
MQMELHTGIDLAVALIQQDNLPDLLRTATRQLENAFGLTRCWALELDLSGRTLHCSDLAE
QGEFDCGDFSHPFAHVLQTGKARELTRAASYRLDHVGFQALFEASDRPRSLWLEPLTGND
GRTLGMLVLCRDEADWDGITGQPLYCGLRQLLVHQWITQLQSRDQVWQRRLLKRSLDHLH
DAETVRTRCEQLALTLVGNSQAMTSLRAQIVRAAGSQLSVLVQGETGCGKDVVARGIHEL
SDRAEGPMVVVNCAAIPDTLLESELFGHTRGAFSGADQDKQGLLAQANGGTLFLDEIGDM
PMALQSKLLRVLESRQFRPLGAREEQHSDFRLVAATHQPLQAGIEDGSFRRDLFYRLSQF
PLRVTPLRERPDDLEALCRHFIRLYTEREGSGPMGISSHALHLLAGYDFPGNVRELRNII
ELACLQTPCGDDIQPEVLRINDLFEESDGWTSPPWDVRDRHPIDLPAVEEIRDLKAAAQA
FEAAIIRERLRQYGGNRAQAAESLGLPKRTLAHKCLKYQVAES