Protein Info for HP15_3438 in Marinobacter adhaerens HP15

Annotation: lipid A export ATP-binding/permease protein msbA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 607 transmembrane" amino acids 40 to 61 (22 residues), see Phobius details amino acids 88 to 111 (24 residues), see Phobius details amino acids 172 to 190 (19 residues), see Phobius details amino acids 196 to 213 (18 residues), see Phobius details amino acids 296 to 320 (25 residues), see Phobius details PF00664: ABC_membrane" amino acids 75 to 324 (250 residues), 117.1 bits, see alignment E=1.2e-37 PF00005: ABC_tran" amino acids 387 to 535 (149 residues), 116 bits, see alignment E=2.2e-37

Best Hits

KEGG orthology group: K06148, ATP-binding cassette, subfamily C, bacterial (inferred from 64% identity to hch:HCH_00591)

Predicted SEED Role

"Lipid A export ATP-binding/permease protein MsbA" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PFD1 at UniProt or InterPro

Protein Sequence (607 amino acids)

>HP15_3438 lipid A export ATP-binding/permease protein msbA (Marinobacter adhaerens HP15)
MEHPQNSVTGIDTRETRQQYTWRDIFGLALKHKPRLVRANLLAIMATVMSVPVPLLLPVL
VDEVLLDEPGPVLPVMDSFLPGSWETPVVYIGLMVVVAFLLRVAALSFNVLQSREFSKVS
KDVVFRIRSRLLGRLQRVAMSEYETRGSGGISSHFITDLDTVDQFLGTTISRFLVASLTV
LGTAGVLLWVHWELGLLILLFNPLVIFATILIGKRVKELKRRENSAYEDFQGDLTETLDA
IHQLRAANREKHYLRQLIDRARNVRDHAIQFEWRSDAASRASFALFQFGVDAFRAAAMVT
VLFSDLSIGMMFAIFGYLWFMLTPVQEMLNMQYAWFAANAALGRINRLLDLKEEPRYPAL
ENPFRDRHTVGLTLRNIHFAYGEEQVLRGINLELAPGEKVALVGASGGGKSTLIQVILGM
YTPQQGEVLIDGVPVERIGLPCLREHVATVLQHPALFNDTVRQNLTLGRDKPDAALWDAL
RIAQLDGTVAAMHDQLDTVIGRQGVRLSGGQRQRLAIARMILSEPSVVILDEATSALDAE
TEFQLHRDLEAFLKQRTTLIIAHRLSAVKQADRACVFEDGRIIEEGHHDELIAREGLYAQ
LYGERQM