Protein Info for PGA1_c35020 in Phaeobacter inhibens DSM 17395

Annotation: heat-inducible transcription repressor HrcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 358 TIGR00331: heat-inducible transcription repressor HrcA" amino acids 13 to 353 (341 residues), 297.4 bits, see alignment E=9.4e-93 PF03444: HrcA_DNA-bdg" amino acids 14 to 77 (64 residues), 21.6 bits, see alignment E=1.4e-08 PF01628: HrcA" amino acids 119 to 340 (222 residues), 192.6 bits, see alignment E=9.2e-61

Best Hits

Swiss-Prot: 53% identical to HRCA_BRADU: Heat-inducible transcription repressor HrcA (hrcA) from Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)

KEGG orthology group: K03705, heat-inducible transcriptional repressor (inferred from 80% identity to sit:TM1040_2873)

Predicted SEED Role

"Heat-inducible transcription repressor HrcA" in subsystem Heat shock dnaK gene cluster extended

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7ES01 at UniProt or InterPro

Protein Sequence (358 amino acids)

>PGA1_c35020 heat-inducible transcription repressor HrcA (Phaeobacter inhibens DSM 17395)
MNSSTDILKDMNDRSRDVFRAVVESYLETGDPVGSRTLTRSLNEKVSAATVRNVMQDLEH
LGLLNSPHTSAGRVPTQVGLRMFVDGLLEVGDLNTQDRQKIDETMGGTAGGGAAGLAGML
DRVGSALSGVTQGASLVLTPKHEAEIRHIEFVTLAHDRALVVLVFSDGHVENRLFTPPPG
QTPSSMREAANFLNALIEGRTLGDVRGAIQEEIKARQQQIDVLAREMIESGLAAWEDDGS
DSARLIVRGRSNLLSDGGAAEELDRIRNLFDDLERKRDIEEFLQLTEDGEGVRIFIGSEN
KLFSLSGSSLVVSPYMNADRKIIGAVGVIGPTRLNYGRIVPIVDYTAQLVGKLLSDRS