Protein Info for HP15_3362 in Marinobacter adhaerens HP15

Annotation: diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 867 transmembrane" amino acids 28 to 49 (22 residues), see Phobius details amino acids 217 to 237 (21 residues), see Phobius details amino acids 246 to 272 (27 residues), see Phobius details amino acids 278 to 297 (20 residues), see Phobius details amino acids 309 to 329 (21 residues), see Phobius details amino acids 336 to 353 (18 residues), see Phobius details amino acids 364 to 384 (21 residues), see Phobius details amino acids 396 to 414 (19 residues), see Phobius details PF07696: 7TMR-DISMED2" amino acids 82 to 204 (123 residues), 49.3 bits, see alignment E=1e-16 PF07695: 7TMR-DISM_7TM" amino acids 219 to 413 (195 residues), 65.4 bits, see alignment E=1.4e-21 PF00990: GGDEF" amino acids 452 to 598 (147 residues), 31.3 bits, see alignment E=3.4e-11 PF00563: EAL" amino acids 628 to 862 (235 residues), 222.8 bits, see alignment E=8.6e-70

Best Hits

KEGG orthology group: None (inferred from 58% identity to maq:Maqu_3605)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PRM9 at UniProt or InterPro

Protein Sequence (867 amino acids)

>HP15_3362 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) (Marinobacter adhaerens HP15)
MDDSTHQTEKAVLSQLRAQSGLTPFRRWMPFLFLMAAMAYGLLASLLQAPENPLSALSQV
DSPEPASQSSRIVQIDYLVAPLEQVIEDENWRQKNWQAAPSENSGIGYYNGPVTFKVTVE
NPGATNAEQWVLVSAPYIDRLRPAILDENGAFQRLRDMGDLYPFGNRLISLPPWIWPVSL
PAGTTTLLFEVQNAGPTLLPISILEPDKVVSDIAGTMTWKAFITGLLVFALLLNLSFMMK
FRLPGLAWLGVLTLSVIHVQLVMEGFGLWLIWPDFPEINALLNISLCLCLISLCQITPNF
IQVSRLPRLLLNAASVLGLLHLLAMPLRLPLLGQDSFLILALTGGSMILALTLKQARHEV
YARYFALSLLFILLGTVISAARTVGWVPVNSFTDSAFFIGAAAASLILTSGIGRQILEER
KKRLASDIRARQEQTLRSHVEQNYKQLLKTHSVTGKPNRAMLEESLDQLDSHQQPYTVAM
IQLSRFNEIEQALGYRTAEDLLRSYLWELDGFLKRIMGDQLIMIDGYALASIDTSNHAFA
FFHSDAPDTYPEKLKTLMSWLGENFREGRFSLSWSSSVGIAHAPEHGVDASDILSSAGFA
ALDTHQPLTVYDPAIADWQYQQQMLMLDIEEALGNGCIWLEYQPTVRIQDAHIASLEALI
RWQHPDFGTVAPDRWIPLAEQVGMIHHVTLWVVDRVCEDMSALKARHGDHIAVAVNISAN
DLTHPDFVEKVKAIVQHHGAQPSDLILEITETAMMADTALAKVVIRTLSQSGFRIAVDDF
GTGHSSLGTLATFELDELKIDRSFLSDILTQPARQRIFRAALDLGEALDLDVVVEGVEEE
AIAAWLQQFPGLYGQGYYWGRPEQLKT