Protein Info for PGA1_c34490 in Phaeobacter inhibens DSM 17395

Annotation: 3-deoxy-manno-octulosonate cytidylyltransferase KdsB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 266 PF02348: CTP_transf_3" amino acids 5 to 232 (228 residues), 119.5 bits, see alignment E=1.9e-38 PF12804: NTP_transf_3" amino acids 31 to 127 (97 residues), 27.7 bits, see alignment E=2.8e-10

Best Hits

Swiss-Prot: 46% identical to KDSB_MARMM: 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB) from Maricaulis maris (strain MCS10)

KEGG orthology group: K00979, 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC: 2.7.7.38] (inferred from 81% identity to sit:TM1040_0014)

Predicted SEED Role

"3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38)" in subsystem KDO2-Lipid A biosynthesis (EC 2.7.7.38)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.38

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7F3S8 at UniProt or InterPro

Protein Sequence (266 amino acids)

>PGA1_c34490 3-deoxy-manno-octulosonate cytidylyltransferase KdsB (Phaeobacter inhibens DSM 17395)
MSVLIVIPARYASTRYPGKPLVALTGASGESQTLIERSWRAAMAVNGVDRVVVATDDERI
RGAATGFGAEVVMTSESCGNGTERCAEALATLEGGYDIVVNLQGDAPLTPHWFVEDLISG
LRDAPDKGLATPVLRCDGATLNSLLADRKAGRVGGTTAVFGRDNNALYFSKEVVPFTSTA
YEADQDTPVFHHVGVYAYRPDALSAYPGWPVGPLETLEGLEQLRFLENGRKILCVEVEAR
GREFWELNNPEDVPLIEAMMEKMGHK