Protein Info for HP15_3325 in Marinobacter adhaerens HP15

Annotation: DSBA oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 211 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF13462: Thioredoxin_4" amino acids 42 to 183 (142 residues), 28.2 bits, see alignment E=2e-10 PF01323: DSBA" amino acids 90 to 184 (95 residues), 49.5 bits, see alignment E=4.6e-17

Best Hits

Swiss-Prot: 42% identical to DSBA_PSEAE: Thiol:disulfide interchange protein DsbA (dsbA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03673, thiol:disulfide interchange protein DsbA (inferred from 76% identity to maq:Maqu_3568)

Predicted SEED Role

"Periplasmic thiol:disulfide interchange protein DsbA" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PRJ2 at UniProt or InterPro

Protein Sequence (211 amino acids)

>HP15_3325 DSBA oxidoreductase (Marinobacter adhaerens HP15)
MFRSFRTAFLLLLALSVTGLANAAEWKEGVHYNRLDNPVRTDSDSGVEVAEVFWYGCPHC
YRFKPLVEEWAANAPDYVNYVKIPAALGRNWEPHAYAFYALEAMGELDKVHDALFDALAG
ERRPLNTPEALADFVAEYGVDPDEFVSTYKSFGVNARMQKAQSKIRGARITGTPTMLVNG
KYTVSASMAGSHEAVLDVVDYLVAKERGDVE