Protein Info for HP15_3318 in Marinobacter adhaerens HP15

Annotation: phosphomannomutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 430 to 560 (131 residues), 133.7 bits, E=7.6e-43
• PF02879: PGM_PMM_II
  • amino acids 575 to 672 (98 residues), 97.5 bits, E=1.3e-31
• PF02880: PGM_PMM_III
  • amino acids 677 to 783 (107 residues), 78.1 bits, E=1.2e-25
• PF00408: PGM_PMM_IV
  • amino acids 792 to 869 (78 residues), 52.1 bits, E=1.1e-17

Best Hits

KEGG orthology group: K01835, phosphoglucomutase [EC: 5.4.2.2] K01840, phosphomannomutase [EC: 5.4.2.8] (inferred from 74% identity to maq:Maqu_3561)

Predicted SEED Role

"Phosphomannomutase (EC 5.4.2.8) / Phosphoglucomutase (EC 5.4.2.2)" in subsystem Alginate metabolism or Mannose Metabolism (EC 5.4.2.2, EC 5.4.2.8)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• GDP-mannose biosynthesis (4/4 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (4/4 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• glucosylglycerol biosynthesis (4/5 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• glycogen degradation I (6/8 steps found)
• sucrose biosynthesis II (6/8 steps found)
• starch degradation V (3/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• colanic acid building blocks biosynthesis (8/11 steps found)
• β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (2/3 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• glycogen degradation II (4/6 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• sucrose biosynthesis I (from photosynthesis) (6/9 steps found)
• glucose and glucose-1-phosphate degradation (3/5 steps found)
• sucrose degradation II (sucrose synthase) (3/5 steps found)
• starch degradation III (2/4 steps found)
• starch biosynthesis (6/10 steps found)
• chitin biosynthesis (5/9 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (2/5 steps found)
• D-galactose degradation I (Leloir pathway) (2/5 steps found)
• β-(1,4)-mannan degradation (2/7 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (2/8 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (6/14 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (5/19 steps found)
• streptomycin biosynthesis (2/18 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism
• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Nucleotide sugars metabolism
• Pentose phosphate pathway
• Starch and sucrose metabolism
• Streptomycin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.8

Use Curated BLAST to search for 5.4.2.2 or 5.4.2.8

Sequence Analysis Tools

See E4PRI5 at UniProt or InterPro

Protein Sequence (880 amino acids)

>HP15_3318 phosphomannomutase (Marinobacter adhaerens HP15)
MKLGKKKDADASVDEKPAKKAVKKEKTSSSGPKLKRLNSVAVNQSLVVVLAGVIAVALLH
FLVVQPSAKERFESLKVLEADAAALRLNQYFDQVQKSVNGLATQPHVVQALNSRNEIPTT
EVQLADSLPGIEAVHLFPYRDIPRTSSSEGLLGFSGLELARRAETGQRLFPDAFPRDNRW
FVQMATPVRNPTSNAVIGSLLIIFDSGQIQPLLQVVNSSLGGQLALVQTVSGSPRTVVSN
GSGSGNAESRRLSNPDWTVAYTPAKSSAAPVDTVMIALLVGVPALIAAIIVWVLLGGAQK
GLRQDVTALIQWAHKVFGGERVKLPTFRWDMVASTGEVLYRLSQVVDKRVAKAGETAKPR
PAGSGKAGGGAAKGGDEPLFQDKDMPDIDMLDGDEDVLGFGSGDDTVFGSGDTPDVEEVT
LPQVELPQDIFRAYDIRGIVGETLTAEGVEVIGRAIGSEARERGVDSLCIGYDGRHSSPD
LADALARGVMAAGCNVIHVGAVPTPVLYFATHELQTGSGVMVTGSHNPANYNGLKIMLGG
ETLSGEAIQKLYQRIQTGDFASGRGSQSTEDVRRAYLDRIVGDIAVAAPLKVVVDAGNGI
AGELAPMLIEELGCEVIPLYCEVDGDFPNHHPDPGKPANLADLIARVESEGADIGLAFDG
DGDRLGVVTNSGKIIWPDRLMMLFARDVVSRNPGADVLYDVKCSRRLAGVISEAGGRPIM
WKTGHSLMKAKMKETGALLAGEMSGHIFFGERWYGFDDGLYSAARLLEILGIEDRHSDEV
FEDFPDDISTPELNVQVTESSKFDIIKRLGESGDFGDGNISTIDGIRVDYADGWGLCRAS
NTTPVLVLRFEAETDEALERIKSVFRDQLQKAAPDLVADF