Protein Info for HP15_3151 in Marinobacter adhaerens HP15

Annotation: transcriptional regulator, TetR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 203 transmembrane" amino acids 163 to 179 (17 residues), see Phobius details PF00440: TetR_N" amino acids 16 to 61 (46 residues), 61.6 bits, see alignment 4.8e-21 PF08361: TetR_C_2" amino acids 83 to 190 (108 residues), 43.3 bits, see alignment E=3.8e-15

Best Hits

KEGG orthology group: None (inferred from 35% identity to rci:RRC9)

Predicted SEED Role

"Transcription repressor of multidrug efflux pump acrAB operon, TetR (AcrR) family" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PPP4 at UniProt or InterPro

Protein Sequence (203 amino acids)

>HP15_3151 transcriptional regulator, TetR family (Marinobacter adhaerens HP15)
MRRTKEDAEKTRQTVLEAALKLFSRDGYSLTTLSRIAKEAGCSRGPIYWHFENKDDLYEA
VLAYSQEPLEALVAECSGMRETPIEAMDHFIERWLGLLANDRKYRQSFEILLNKTELTDA
MSRTLKRERALTKSIITMFRDLVGQAAERGLISTQEDPKDLGLLSYTYLMGITQTWLFAP
KLFSLKRETAFFQRQFWVLLGRG