Protein Info for HP15_3149 in Marinobacter adhaerens HP15

Annotation: urea amidolyase related protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1208 PF00289: Biotin_carb_N" amino acids 7 to 115 (109 residues), 144.5 bits, see alignment E=5.9e-46 TIGR02712: urea carboxylase" amino acids 7 to 1204 (1198 residues), 1880.2 bits, see alignment E=0 PF02786: CPSase_L_D2" amino acids 121 to 324 (204 residues), 208.8 bits, see alignment E=2.6e-65 PF07478: Dala_Dala_lig_C" amino acids 149 to 296 (148 residues), 33.7 bits, see alignment E=9.5e-12 PF02785: Biotin_carb_C" amino acids 343 to 449 (107 residues), 117.6 bits, see alignment E=9.7e-38 TIGR00724: biotin-dependent carboxylase uncharacterized domain" amino acids 458 to 774 (317 residues), 304.3 bits, see alignment E=8.6e-95 PF02626: CT_A_B" amino acids 481 to 753 (273 residues), 314.6 bits, see alignment E=2.3e-97 PF02682: CT_C_D" amino acids 804 to 1024 (221 residues), 143.4 bits, see alignment E=2.7e-45 PF00364: Biotin_lipoyl" amino acids 1143 to 1202 (60 residues), 52.5 bits, see alignment 1.3e-17

Best Hits

KEGG orthology group: K01941, urea carboxylase [EC: 6.3.4.6] (inferred from 66% identity to abo:ABO_1892)

Predicted SEED Role

"Urea carboxylase (EC 6.3.4.6)" in subsystem Urea decomposition (EC 6.3.4.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PPP2 at UniProt or InterPro

Protein Sequence (1208 amino acids)

>HP15_3149 urea amidolyase related protein (Marinobacter adhaerens HP15)
MELSGRFSKVLIANRGAIACRVIRTLRDMGLTSVAVYAKADSDSLHVRQADEAYSLGDGP
AATTYLDQDKLFEVIRKSGAGAIHPGYGFLSENADFARRCDAEGVVFLGPTPEQMEQFGL
KHTARSLAESAGVPLLPGTGLLTNLEEAIKAADTIGYPVMLKSTAGGGGIGMSRCYGPDD
LGKSFESVQRLSQNNFSNSGVFLEKFVEHARHVEVQLFGDGQGQVLALGERDCSAQRRNQ
KVIEEAPAPGLSDDVRSRMHATARQLGKSIGYRSAGTVEFIYDPDTTEFYFLEVNTRLQV
EHGVTEQVYGVDLVRWMVELGAGTLPDLAKLGSNLAPSGHAIQARIYAEDPNKDFQPGAG
LLTNVAWPEDEALRIDTWIQPGTEVSPLYDPMLAKVIVHEADRESARQRLMQALDDSQLY
GIETNLKYVRQVLDDPRFAEGRLFTRTLNEFDYQPATVDVLSGGTLTTIQDYPGRIGYWE
IGVPPSGPFDSYSFRLGNRLLGNPEGAPGLEITLKGPVLTFNRATQIALTGAQLDATLDD
QPVASWQVINVPAGATLKLGATTADGARAYVLFRGGLDCPEYLTSCSTFTLGQFGGHCGR
ALRAGDVLALADSESAPLITLPAELKPTIGKTWKLHVTYGPHGAPDYFTEEDINTFFASD
WEIHYNSSRTGVRLIGPKPQWARSDGGEAGMHPSNIHDNAYAVGTVDFTGDMPVILGPDG
PSLGGFVCPVTVISADLWKLGQLKAGDKVQFVPVSQDQAVALREALDESIATLTAATAHI
KPITPTSPVLAALSDDEHETGVVYRAAGDNYVLVEYGPMELDIRLRFRAHALMLWLREQN
HDAILELTPGIRSLQVHYDSQKLNQRTLLDLLIGAEKELEKQPEWDVPARIVHLPLSWDD
EACQTAIAKYMQSVRKDAPWCPSNLEFIRRINGLDSIDEVKKTLFEATYLVMGLGDVYLG
APVATPLDPRHRLVTTKYNPARTWTAENSVGIGGAYLCIYGMEGPGGYQFVGRTLQMWNR
YRTTDLFEAGKPWLLRFFDQVRFYEVSAEELQQIRRDFPNGDYPIKVEETRFNLKDYEQF
LANNDDEIQTFTAKRKQAFDEELQRWIESGQINFSSEAPIEDTGEDDIANLPAGQHAVES
HVAGNLWECLVKPGDTIDAQRPVAVIESMKMEIELLSPVTGRVVDVRREAGQAVSPGTPV
VIVEEITE