Protein Info for PGA1_c00320 in Phaeobacter inhibens DSM 17395

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1127 TIGR00594: DNA polymerase III, alpha subunit" amino acids 30 to 1035 (1006 residues), 474.5 bits, see alignment E=4.1e-146 PF02811: PHP" amino acids 33 to 121 (89 residues), 35.4 bits, see alignment E=3.6e-12 PF07733: DNA_pol3_alpha" amino acids 334 to 588 (255 residues), 270.5 bits, see alignment E=4.2e-84 PF17657: DNA_pol3_finger" amino acids 591 to 756 (166 residues), 182 bits, see alignment E=1.5e-57 PF14579: HHH_6" amino acids 830 to 918 (89 residues), 62.3 bits, see alignment E=1.1e-20 PF01336: tRNA_anti-codon" amino acids 1000 to 1073 (74 residues), 40.8 bits, see alignment 4.3e-14

Best Hits

Swiss-Prot: 78% identical to DNAE2_RUEPO: Error-prone DNA polymerase (dnaE2) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

KEGG orthology group: K14162, error-prone DNA polymerase [EC: 2.7.7.7] (inferred from 77% identity to sit:TM1040_0175)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EVH0 at UniProt or InterPro

Protein Sequence (1127 amino acids)

>PGA1_c00320 DNA polymerase III subunit alpha (Phaeobacter inhibens DSM 17395)
MIEVNRIHRPVEAFQREMLAKHIDAPDYAELCVTTNFTFLTGASHPEELIVRAAELGLSA
LAITDHNSLAGVVRAWSALKELKRDPQDALKIRSQHQVDSSSRQEIGHTSALPKPTTPIF
PKLIVGCRLILQNCAVDWIALPCDRSAYKRLARLLTLGKRRAEKGQCLLYAEDMIDACKG
MILIALPKETLSNAVSDIQKIGRQFPNHVFLGATPRYDGSDQAYLAACAKLAQTTCAPMV
AVGDVLMHRANRRQLADVLTCMRENINIDDIGTRALPNAERRLKAGADMARIFRDHPAAL
RRTAEIANRCNFDLSELSYEYPHEEAEGETPQDRLERLAREGLKRRYPDGPPDRAIKLME
KELSAVKDLEFPAYFLTVHDIVQFARSKGILCQGRGSAANSILCYLLGITDVSPDMIAMV
FERFVSKHRGEPPDIDVDFEHERREEVIQWIYQKYGRHRAGLCATVIHFRTRAAIREVGK
VMGLSQDVTAGLSGQIWGMSNGSVDLERIRELGLNLEDRRLMQTIRLIGEIIGFPRHLSQ
HVGGFVITSGRLDELAPIENAAMENRTVICWDKDDIDALRILKVDILALGMLTCIRKAFA
LMQQHENITHSIATIPQKDEATYDMLCAADAVGVFQVESRAQMNFLPRMRPREFYDLVIE
VAIVRPGPIQGDMVRPYIRRRNGLEKPDPFGPQLEQVTRRTKGVPLFQEQALQIAVVGAG
FSAEEADHLRRSLASFRRMGTISKYRDKFIAGMLKNKYSREIAERCFGQIEGFADYGFPE
SHAAAFAMLAYVSAWLKCHHPAIFACALLNSQPMGFYAPAQIVRDVRDHGIEVRPICVNQ
SQWDNSLERRPDGTLALRLGFRQIKGFKEDDTGWIIAARGNGYIDPEHLWLRAGLAPAAL
ERLAEADAFSSMGISRRDALWQVKSITTPAPLPLFNDQLDGEAINEPNVMLPRMHLGEEV
VEDYVSMRLSLRAHPMELLRPTLPGLTCNDQLIKAPLQRVSVGGLVITRQRPGTASGVIF
LTLEDETGVCNVVVWKKIYERFRRIVMGGRLLCVTGYLQREGTIVHVIAQHIEDESARLS
ELGHPLDGAIQSEGPRADDTPKRTRYPARAMHPRDQAKRLFPSRDFH