Protein Info for HP15_3035 in Marinobacter adhaerens HP15

Annotation: transporter, AcrB/D/F family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1008 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 330 to 348 (19 residues), see Phobius details amino acids 354 to 372 (19 residues), see Phobius details amino acids 378 to 402 (25 residues), see Phobius details amino acids 423 to 446 (24 residues), see Phobius details amino acids 458 to 482 (25 residues), see Phobius details amino acids 514 to 533 (20 residues), see Phobius details amino acids 842 to 861 (20 residues), see Phobius details amino acids 869 to 888 (20 residues), see Phobius details amino acids 895 to 918 (24 residues), see Phobius details amino acids 943 to 963 (21 residues), see Phobius details amino acids 969 to 991 (23 residues), see Phobius details PF00873: ACR_tran" amino acids 14 to 991 (978 residues), 476.5 bits, see alignment E=2.4e-146 PF03176: MMPL" amino acids 332 to 511 (180 residues), 20.7 bits, see alignment E=2.8e-08 amino acids 840 to 995 (156 residues), 30.4 bits, see alignment E=3e-11 PF02355: SecD_SecF" amino acids 840 to 995 (156 residues), 24.5 bits, see alignment E=2.4e-09

Best Hits

KEGG orthology group: None (inferred from 85% identity to maq:Maqu_3312)

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PNW9 at UniProt or InterPro

Protein Sequence (1008 amino acids)

>HP15_3035 transporter, AcrB/D/F family (Marinobacter adhaerens HP15)
MTRRLLNCQRLLGMVVTMLCLLGIAAYSTMPRQEDPSFPYRAGLISINYPGASAEAVERL
VLRPLVDELRQVEGVDYTQSTARTGVAIVRLRLNDDIYDTDPAWDRVRQAMERAKQDFPD
DVGRMVLDDRLIDIPAIVMAVGGSPSVTELSDVAERLKQNLSDLPGVSRIELEGDADEQI
TLALDDAALFRLGISPARVLDTLARRNQTIPGGFVVVNGRRLSVLPNSEFADIDAIRATP
IELPDGSQVPLAAAADVWRGPVEPRQPETWYDGERVVLVSIIMEEGTTDAIRFGQRVRER
MEQIRGDFEPYEIREMFFQPDKVQERLDNLAWSLVLSVLIIVAVVFTGMGIRMGLLVASI
LPMVALISVGLYDLGGGVLHQIAVIGMVISLGILIDNAIVIVENIQGHLDEGMRRLDALR
QAVSELAGPLGASTGTTLAAFAPLLLAKGGAADFTRGVPVMIMLTLSVSYLLAISAVPLL
AARFLKPRRKAGQDRLIGVARFLGGLVSRYPGRLITAGAILVGISLAMTPFMAQQFFPNA
DRPRVIVEVYMPEGTDQARTAEATESLERIIRSQPDALKVHRFVGFTGPSFYYNLQRAPQ
APNRARLVVTTPTLEDTTGMIRWIRAHVKEQMPELDVTVGILGQGPPRAAPVEIRVYHVN
DGARIEAVERIFSILRGVEGTVDVRHDLDIGVPSIAINVDDATAARYGLTRADVAQSLYG
QSFGVVAERYRQEEDPIPLVLRSREGTALSLSRLLSVNIYNDRGDAVPLSAVATVDTTWE
PAARYLRDGVRMNTVTANLETGYSFSQALDGLYAGLEKNPLPPGTRMAMGGDAEGSGEAN
TALLTAAPIGMLLLLFFLLLQFNSFRRVGIILLTVPLATVGIFPGLVLSGSPFGFQSLLG
VIALVGIVVNNAIVLLDVMDRELEKGRDIRDAMRNAVEQRTRPILLTTATTVAGLLPLAF
SSSTLWPPMAWAIISGLLASTVLTLLVIPAVCTQLIKVSVPEPENAPA