Protein Info for HP15_3019 in Marinobacter adhaerens HP15

Annotation: Na+/Ca+ antiporter, CaCA family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 323 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 77 to 99 (23 residues), see Phobius details amino acids 107 to 123 (17 residues), see Phobius details amino acids 129 to 148 (20 residues), see Phobius details amino acids 175 to 196 (22 residues), see Phobius details amino acids 208 to 230 (23 residues), see Phobius details amino acids 241 to 263 (23 residues), see Phobius details amino acids 275 to 292 (18 residues), see Phobius details amino acids 304 to 321 (18 residues), see Phobius details TIGR00367: K+-dependent Na+/Ca+ exchanger homolog" amino acids 5 to 313 (309 residues), 265 bits, see alignment E=4.2e-83 PF01699: Na_Ca_ex" amino acids 7 to 147 (141 residues), 104.5 bits, see alignment E=2.7e-34 amino acids 174 to 318 (145 residues), 143.7 bits, see alignment E=2.2e-46

Best Hits

Swiss-Prot: 50% identical to CAXA_ALKAM: Putative antiporter CaxA (caxA) from Alkalimonas amylolytica

KEGG orthology group: K07301, inner membrane protein (inferred from 79% identity to maq:Maqu_3291)

Predicted SEED Role

"Inner membrane protein YrbG, predicted calcium/sodium:proton antiporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PNV3 at UniProt or InterPro

Protein Sequence (323 amino acids)

>HP15_3019 Na+/Ca+ antiporter, CaCA family (Marinobacter adhaerens HP15)
MIEMLMAIGAIIAGLILLVWSADKFVEGSATTASHFGMPPLLIGMVVVGFGTSAPEMAVS
ALAASQGNPGLALGNAYGSNITNIALILGITALLAPIAVHSQVMRKELPILILVTAFAGW
QLWDGDLSRMDAIGLMLAFVALIGWSIYQGRRQPDDALATEMTEEVHAMPVRKAILWLVV
GLLLLIVSSRILVWGAVDLATTFGISDLVIGLTIVAVGTSLPELASSIIAARKGEHDLAL
GNILGSNLFNTLAVVGIAGLIAPMPVAPEVLTRDFPVMAALTLVLFAMCYGFRGPGRINR
FEGSALLLAFVAYTVYLLAFSGA